主要组织相容性复合体II类分子（MHC-II）的表观遗传调控：II类反式激活因子（CIITA）与组蛋白修饰酶之间的相互作用
Epigenetic control of MHC-II: interplay between CIITA and histone-modifying enzymes.
作者信息
Zika Eleni, Ting Jenny P-Y
机构信息
Lineberger Comprehensive Cancer Center, CB#7295, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
出版信息
Curr Opin Immunol. 2005 Feb;17(1):58-64. doi: 10.1016/j.coi.2004.11.008.
Recent advances have shown the crucial role of histone-modifying enzymes in controlling gene activation and repression. This led to the 'histone code' hypothesis, which proposes that combinations of histone modifications work in concert to affect specific gene expression. Mounting evidence suggests that the class II transactivator modulates promoter accessibility by coordinating the recruitment of chromatin modifiers in a time-dependent fashion. MHC-II expression is exquisitely controlled by these highly specific, coordinated and dynamic interactions at the promoter.
最近的进展表明，组蛋白修饰酶在控制基因激活和抑制中起着关键作用。这导致了“组蛋白密码”假说，该假说提出组蛋白修饰的组合协同作用以影响特定基因的表达。越来越多的证据表明，II类反式激活因子通过以时间依赖性方式协调染色质修饰因子的募集来调节启动子的可及性。MHC-II的表达受到启动子处这些高度特异性、协调性和动态性相互作用的精确控制。
Zotero 插件