Tu Yadan, Chen Yong, Li Xuanhan, Wang Yigang, Fang Bangjiang, Ren Yi, Wang Chenghu
Department of Classic Chinese Medicine, The First Affiliated Hospital of Chongqing University of Chinese Medicine, Chongqing, China.
Classic Department of Traditional Chinese Medicine, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China.
Ther Adv Respir Dis. 2025 Jan-Dec;19:17534666241308408. doi: 10.1177/17534666241308408. Epub 2025 Mar 17.
Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is the main cause of hospitalization and death of patients with chronic obstructive pulmonary disease. This is largely due to bacterial resistance caused by clinical antibiotic abuse and the limited efficacy of current treatment strategies in managing noninfectious AECOPD, which presents a significant challenge for clinicians. Therefore, it is urgent for clinical treatment and prevention of AECOPD to fully understand the specific mechanism of AECOPD in the immune system and master the key differences between infectious factors and noninfectious factors. This article systematically discusses AECOPD triggered by various factors, including the activation of immune system, the recruitment and activation of inflammatory cells and the role of specific inflammatory responses, and through a comprehensive review of the literature, this article expounds the existing targeted diagnosis and treatment methods and technologies at different stages in order to provide new ideas and strategies for clinical prevention and treatment of AECOPD.
慢性阻塞性肺疾病急性加重（AECOPD）是慢性阻塞性肺疾病患者住院和死亡的主要原因。这在很大程度上归因于临床抗生素滥用导致的细菌耐药性以及当前治疗策略在管理非感染性AECOPD方面疗效有限，这给临床医生带来了重大挑战。因此，对于AECOPD的临床治疗和预防而言，全面了解其在免疫系统中的具体机制并掌握感染因素与非感染因素之间的关键差异迫在眉睫。本文系统地探讨了由各种因素引发的AECOPD，包括免疫系统的激活、炎症细胞的募集和激活以及特异性炎症反应的作用，并且通过对文献的全面综述，阐述了不同阶段现有的靶向诊断和治疗方法及技术，以便为AECOPD的临床预防和治疗提供新的思路和策略。
