NLR 和 ALR 家族成员的炎性小体非依赖性作用。

Inflammasome-Independent Roles of NLR and ALR Family Members.

机构信息

Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

出版信息

Methods Mol Biol. 2023;2696:29-45. doi: 10.1007/978-1-0716-3350-2_2.

DOI:10.1007/978-1-0716-3350-2_2

PMID:37578713

Abstract

Pattern recognition receptors, including members of the NLR and ALR families, are essential for recognition of both pathogen- and host-derived danger signals. Several members of these families, including NLRP1, NLRP3, NLRC4, and AIM2, are capable of forming multiprotein complexes, called inflammasomes, that result in the activation of pro-inflammatory caspase-1. However, in addition to the formation of inflammasomes, a number of these family members exert inflammasome-independent functions. Here, we will discuss inflammasome-independent functions of NLRC4, NLRP12, and AIM2 and examine their roles in regulating innate and adaptive immune processes.

摘要

模式识别受体，包括 NLR 和 ALR 家族的成员，对于识别病原体和宿主来源的危险信号至关重要。这些家族的几个成员，包括 NLRP1、NLRP3、NLRC4 和 AIM2，能够形成多蛋白复合物，称为炎性体，导致炎症性半胱天冬酶-1 的激活。然而，除了炎性体的形成外，这些家族成员中的许多还发挥炎性体非依赖性功能。在这里，我们将讨论 NLRC4、NLRP12 和 AIM2 的炎性体非依赖性功能，并研究它们在调节先天和适应性免疫过程中的作用。