阿扑吗啡在亨廷顿舞蹈症动物模型中的镇静作用。

Sedative effects of apomorphine in an animal model of Huntington's disease.

作者信息

Sanberg P R, Lehmann J, Fibiger H C

出版信息

Arch Neurol. 1979 Jun;36(6):349-50. doi: 10.1001/archneur.1979.00500420059006.

DOI:10.1001/archneur.1979.00500420059006

Abstract

The sedative effectiveness of apomorphine in a newly developed animal model of Huntington's disease was examined. The motor responses of rats with kainic acid lesions of the neostriatum to a sedative dose of apomorphine (50 micrograms/kg) was similar to that observed in intact controls. In contrast, compared to controls, a marked potentiation of the motor stimulant effects of dextroamphetamine was confirmed in the kainic acid-lesioned group. We suggest that the pathological changes underlying the symptoms observed in this animal model and in Huntington's disease do not include abnormalities in presynaptic dopamine receptors in the neostriatum.

摘要

研究了阿扑吗啡在新建立的亨廷顿病动物模型中的镇静效果。用 kainic 酸损伤新纹状体的大鼠对阿扑吗啡镇静剂量（50 微克/千克）的运动反应与未受损对照组相似。相反，与对照组相比，在 kainic 酸损伤组中证实右旋苯丙胺的运动刺激作用有明显增强。我们认为，在该动物模型和亨廷顿病中观察到的症状所潜在的病理变化不包括新纹状体中突触前多巴胺受体的异常。