Kafetzopoulos E, Vlaha V, Konitsiotis S
Department of Pharmacology, Medical School, University of Ioannina, Greece.
Pharmacol Biochem Behav. 1988 Feb;29(2):403-6. doi: 10.1016/0091-3057(88)90176-1.
Rats with total, dorsal or ventral ibotenic acid striatal lesions were challenged with DA agonists apomorphine and d-amphetamine. In rats with total lesions, both drugs induced an intense ipsilateral rotation, as did apomorphine in the dorsally lesioned rats. Amphetamine induced ipsilateral rotation in ventrally lesioned rats, but this effect may represent a non-specific potentiation of spontaneous ipsilateral rotation observed in this group. These results indicate that the neostriatum of the rat is not an homogeneous structure concerning the expression of rotational behavior after DA receptor stimulation.
给纹状体注射鹅膏蕈氨酸造成全部、背侧或腹侧损伤的大鼠注射多巴胺激动剂阿扑吗啡和右旋苯丙胺进行激发试验。在全部损伤的大鼠中，这两种药物均诱发强烈的同侧旋转，背侧损伤的大鼠注射阿扑吗啡时也出现这种情况。苯丙胺在腹侧损伤的大鼠中诱发同侧旋转，但这种效应可能代表该组中观察到的自发同侧旋转的非特异性增强。这些结果表明，就多巴胺受体刺激后旋转行为的表现而言，大鼠的新纹状体并非均质结构。
