CX3CR1介导的树突状细胞进入肠腔及细菌清除。
CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance.
作者信息
Niess Jan Hendrik, Brand Stephan, Gu Xiubin, Landsman Limor, Jung Steffen, McCormick Beth A, Vyas Jatin M, Boes Marianne, Ploegh Hidde L, Fox James G, Littman Dan R, Reinecker Hans-Christian
机构信息
Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.
出版信息
Science. 2005 Jan 14;307(5707):254-8. doi: 10.1126/science.1102901.
Dendritic cells (DCs) and macrophages are critical to innate and adaptive immunity to the intestinal bacterial microbiota. Here, we identify a myeloid-derived mucosal DC in mice, which populates the entire lamina propria of the small intestine. Lamina propria DCs were found to depend on the chemokine receptor CX3CR1 to form transepithelial dendrites, which enable the cells to directly sample luminal antigens. CX3CR1 was also found to control the clearance of entero-invasive pathogens by DCs. Thus, CX3CR1-dependent processes, which control host interactions of specialized DCs with commensal and pathogenic bacteria, may regulate immunological tolerance and inflammation.
树突状细胞（DCs）和巨噬细胞对于肠道细菌微生物群的固有免疫和适应性免疫至关重要。在此，我们在小鼠中鉴定出一种髓系来源的黏膜DC，它分布于小肠的整个固有层。发现固有层DC依赖趋化因子受体CX3CR1形成跨上皮树突，这使细胞能够直接摄取管腔抗原。还发现CX3CR1可控制DC对肠道侵袭性病原体的清除。因此，依赖CX3CR1的过程控制着特殊DC与共生菌和病原菌的宿主相互作用，可能调节免疫耐受和炎症。
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