巴西茅膏菜的抗菌活性及化学研究。

Antimicrobial activity and chemical investigation of Brazilian Drosera.

作者信息

Ferreira Dalva Trevisan, Andrei César Cornélio, Saridakis Halha Ostrensky, Faria Terezinha de Jesus, Vinhato Elisângela, Carvalho Kátia Eliane, Daniel Juliana Feijó Souza, Machado Sílvio Luiz, Saridakis Dennis Panayotis, Braz-Filho Raimundo

机构信息

Departamento de Química, Centro de Ciências Exatas, Universidade Estadual de Londrina, Caixa Postal 6001, 86051-970 Londrina, PR, Brazil.

出版信息

Mem Inst Oswaldo Cruz. 2004 Nov;99(7):753-5. doi: 10.1590/s0074-02762004000700016. Epub 2005 Jan 12.

DOI:10.1590/s0074-02762004000700016

PMID:15654434

Abstract

The antimicrobial activity of three different extracts (hexanic, ethyl acetate, methanol) obtained from Brazilian Drosera species (D. communis, D. montana var. montana, D. brevifolia, D. villosa var. graomogolensis, D. villosa var. villosa, Drosera sp. 1, and Drosera sp. 2 ) were tested against Staphylococcus aureus (ATCC 25923), Enterococcus faecium (ATCC23212), Pseudomonas aeruginosa (ATCC27853), Escherichia coli (ATCC11229), Salmonella choleraesuis (ATCC10708), Klebsiella pneumoniae (ATCC13883), and Candida albicans (a human isolate). Better antimicrobial activity was observed with D. communis and D. montana var. montana ethyl acetate extracts. Phytochemical analyses from D. communis, D. montana var. montana and D. brevifolia yielded 5-hydroxy-2-methyl-1,4-naphthoquinone (plumbagin); long chain aliphatic hydrocarbons were isolated from D. communis and from D. villosa var. villosa, a mixture of long chain aliphatic alcohols and carboxylic acids, was isolated from D. communis and 3b-O-acetylaleuritolic acid from D. villosa var. villosa.

摘要

对从巴西茅膏菜属植物（茅膏菜、山地茅膏菜、短叶茅膏菜、绒毛茅膏菜格劳莫戈伦西斯变种、绒毛茅膏菜绒毛变种、茅膏菜物种1和茅膏菜物种2）中获得的三种不同提取物（己烷提取物、乙酸乙酯提取物、甲醇提取物）进行了抗菌活性测试，测试对象包括金黄色葡萄球菌（ATCC 25923）、粪肠球菌（ATCC23212）、铜绿假单胞菌（ATCC27853）、大肠杆菌（ATCC11229）、猪霍乱沙门氏菌（ATCC10708）、肺炎克雷伯菌（ATCC13883）和白色念珠菌（一株人体分离株）。观察到茅膏菜和山地茅膏菜的乙酸乙酯提取物具有更好的抗菌活性。对茅膏菜、山地茅膏菜和短叶茅膏菜的植物化学分析得到了5-羟基-2-甲基-1,4-萘醌（白花丹醌）；从茅膏菜和绒毛茅膏菜绒毛变种中分离出了长链脂肪烃，从茅膏菜中分离出了长链脂肪醇和羧酸的混合物，从绒毛茅膏菜绒毛变种中分离出了3β-O-乙酰齐墩果酸。