Kantor A B, Stall A M, Adams S, Herzenberg L A, Herzenberg L A
Department of Genetics, Beckman Center B007, Stanford University Medical Center, CA 94305-5125.
Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3320-4. doi: 10.1073/pnas.89.8.3320.
Cell-transfer studies presented here distinguish three murine B cell lineages: conventional B cells, which develop late and are continually replenished from progenitors in adult bone marrow; Ly-1 B cells (B-1a), which develop early and maintain their numbers by self-replenishment; and Ly-1B "sister" (B-1b) cells, which share many of the properties of Ly-1 B cells, including self-replenishment and feedback regulation of development but can also readily develop from progenitors in adult bone marrow. The sequential emergence of these lineages, the time at which their progenitors function during ontogeny, and the distinctions among their repertoires and functions suggest that evolution has created a layered immune system in which the immune response potential of each successive lineage is adapted to its particular niche.
本文展示的细胞转移研究区分了三种小鼠B细胞谱系：传统B细胞，其发育较晚，且在成年骨髓中不断由祖细胞补充；Ly-1 B细胞（B-1a），其发育较早，并通过自我补充维持数量；以及Ly-1B“姐妹”（B-1b）细胞，它们具有许多Ly-1 B细胞的特性，包括自我补充和发育的反馈调节，但也能很容易地从成年骨髓中的祖细胞发育而来。这些谱系的相继出现、其祖细胞在个体发育过程中发挥作用的时间，以及它们的库和功能之间的差异表明，进化创造了一个分层的免疫系统，其中每个相继谱系的免疫反应潜力都适应其特定的生态位。
