Reche Pedro A, Zhang Hong, Glutting John-Paul, Reinherz Ellis L
Laboratory of Immunobiology and Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Bioinformatics. 2005 May 1;21(9):2140-1. doi: 10.1093/bioinformatics/bti269. Epub 2005 Jan 18.
EPIMHC is a relational database of MHC-binding peptides and T cell epitopes that are observed in real proteins. Currently, the database contains 4867 distinct peptide sequences from various sources, including 84 tumor-associated antigens. The EPIMHC database is accessible through a web server that has been designed to facilitate research in computational vaccinology. Importantly, peptides resulting from a query can be selected to derive specific motif-matrices. Subsequently, these motif-matrices can be used in combination with a dynamic algorithm for predicting MHC-binding peptides from user-provided protein queries.
The EPIMHC database server is hosted by the Dana-Farber Cancer Institute at the site http://immunax.dfci.harvard.edu/bioinformatics/epimhc/
EPIMHC是一个关于在真实蛋白质中观察到的MHC结合肽和T细胞表位的关系数据库。目前，该数据库包含来自各种来源的4867个不同的肽序列，其中包括84种肿瘤相关抗原。可通过一个专门设计用于促进计算疫苗学研究的网络服务器访问EPIMHC数据库。重要的是，可以选择查询结果中的肽来推导特定的基序矩阵。随后，这些基序矩阵可与一种动态算法结合使用，以根据用户提供的蛋白质查询预测MHC结合肽。
EPIMHC数据库服务器由达纳-法伯癌症研究所托管，网址为http://immunax.dfci.harvard.edu/bioinformatics/epimhc/
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