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北爱尔兰急症室非处方药相关过量用药的患病率——一项回顾性评估

Prevalence of over-the-counter drug-related overdoses at Accident and Emergency departments in Northern Ireland--a retrospective evaluation.

作者信息

Wazaify M, Kennedy S, Hughes C M, McElnay J C

机构信息

Clinical and Practice Research Group, The School of Pharmacy, The Queen's University of Belfast, Belfast, UK.

出版信息

J Clin Pharm Ther. 2005 Feb;30(1):39-44. doi: 10.1111/j.1365-2710.2004.00607.x.

Abstract

BACKGROUND AND OBJECTIVES

One major concern associated with misuse/abuse of over-the-counter (OTC) products is the potential for over-dosage. The aim of this research study was to evaluate, over a 3-month period, OTC medicine-related overdoses (those involving OTC drugs only and OTC drugs in combination with other drugs) that led to patients presenting at the Accident and Emergency (A & E) departments in four Belfast hospitals.

METHODS

A data collection sheet was designed to capture the information required from the A & E records in each hospital. A retrospective week-by-week data collection, reviewing A & E records, took place over a 3-month period (starting on 1 December 2002). All data related to cases presenting at the A & E departments because of drug overdoses (either accidental or deliberate according to Read Clinical Classification) were included in the study. Data were coded and entered into a custom designed SPSS database for analysis, using Chi square and Fisher exact tests.

RESULTS

OTC drug-related overdoses comprised 40.1% of all overdoses, of which 24.0% were OTC-only overdoses. Those who overdosed on OTC drugs (solely or combined with other drugs) were mainly female (62.3%) and in the age category 31-50 years (44.9%; P <0.05). The majority (n=215) of OTC-related overdoses were intentional, whereas only 28 were accidental. Of those who attended the A & E departments and had an overdose history, one-third overdosed on OTC-related products and two-thirds overdosed on OTC drugs only.

CONCLUSIONS

OTC drugs accounted for a significant proportion of overdose presentations at the A & E departments in Northern Ireland. Higher awareness of the potential of OTC product use in overdose cases (intentional or accidental) is recommended for both the public and health care professionals.

摘要

背景与目的

与非处方药(OTC)滥用相关的一个主要问题是用药过量的可能性。本研究的目的是在3个月的时间内,评估导致患者前往贝尔法斯特四家医院急诊科就诊的与OTC药物相关的过量用药情况(仅涉及OTC药物以及OTC药物与其他药物联用的情况)。

方法

设计了一份数据收集表,以获取每家医院急诊科记录所需的信息。在3个月期间(从2002年12月1日开始),对急诊科记录进行回顾性逐周数据收集。所有因药物过量(根据瑞德临床分类法,包括意外或故意过量)而到急诊科就诊的病例数据均纳入研究。数据进行编码后输入定制设计的SPSS数据库进行分析,采用卡方检验和费舍尔精确检验。

结果

与OTC药物相关的过量用药占所有过量用药病例的40.1%,其中仅OTC药物过量占24.0%。过量服用OTC药物(单独或与其他药物联用)的患者主要为女性(62.3%),年龄在31 - 50岁之间(44.9%;P<0.05)。大多数(n = 215)与OTC相关的过量用药是故意的,而只有28例是意外的。在前往急诊科且有过量用药史的患者中,三分之一过量服用了与OTC相关的产品,三分之二仅过量服用了OTC药物。

结论

在北爱尔兰的急诊科,OTC药物导致的过量用药病例占相当大的比例。建议公众和医护人员提高对OTC产品在过量用药病例(无论是故意还是意外)中潜在风险的认识。

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