Wazaify M, Kennedy S, Hughes C M, McElnay J C
Clinical and Practice Research Group, The School of Pharmacy, The Queen's University of Belfast, Belfast, UK.
J Clin Pharm Ther. 2005 Feb;30(1):39-44. doi: 10.1111/j.1365-2710.2004.00607.x.
One major concern associated with misuse/abuse of over-the-counter (OTC) products is the potential for over-dosage. The aim of this research study was to evaluate, over a 3-month period, OTC medicine-related overdoses (those involving OTC drugs only and OTC drugs in combination with other drugs) that led to patients presenting at the Accident and Emergency (A & E) departments in four Belfast hospitals.
A data collection sheet was designed to capture the information required from the A & E records in each hospital. A retrospective week-by-week data collection, reviewing A & E records, took place over a 3-month period (starting on 1 December 2002). All data related to cases presenting at the A & E departments because of drug overdoses (either accidental or deliberate according to Read Clinical Classification) were included in the study. Data were coded and entered into a custom designed SPSS database for analysis, using Chi square and Fisher exact tests.
OTC drug-related overdoses comprised 40.1% of all overdoses, of which 24.0% were OTC-only overdoses. Those who overdosed on OTC drugs (solely or combined with other drugs) were mainly female (62.3%) and in the age category 31-50 years (44.9%; P <0.05). The majority (n=215) of OTC-related overdoses were intentional, whereas only 28 were accidental. Of those who attended the A & E departments and had an overdose history, one-third overdosed on OTC-related products and two-thirds overdosed on OTC drugs only.
OTC drugs accounted for a significant proportion of overdose presentations at the A & E departments in Northern Ireland. Higher awareness of the potential of OTC product use in overdose cases (intentional or accidental) is recommended for both the public and health care professionals.
与非处方药(OTC)滥用相关的一个主要问题是用药过量的可能性。本研究的目的是在3个月的时间内,评估导致患者前往贝尔法斯特四家医院急诊科就诊的与OTC药物相关的过量用药情况(仅涉及OTC药物以及OTC药物与其他药物联用的情况)。
设计了一份数据收集表,以获取每家医院急诊科记录所需的信息。在3个月期间(从2002年12月1日开始),对急诊科记录进行回顾性逐周数据收集。所有因药物过量(根据瑞德临床分类法,包括意外或故意过量)而到急诊科就诊的病例数据均纳入研究。数据进行编码后输入定制设计的SPSS数据库进行分析,采用卡方检验和费舍尔精确检验。
与OTC药物相关的过量用药占所有过量用药病例的40.1%,其中仅OTC药物过量占24.0%。过量服用OTC药物(单独或与其他药物联用)的患者主要为女性(62.3%),年龄在31 - 50岁之间(44.9%;P<0.05)。大多数(n = 215)与OTC相关的过量用药是故意的,而只有28例是意外的。在前往急诊科且有过量用药史的患者中,三分之一过量服用了与OTC相关的产品,三分之二仅过量服用了OTC药物。
在北爱尔兰的急诊科,OTC药物导致的过量用药病例占相当大的比例。建议公众和医护人员提高对OTC产品在过量用药病例(无论是故意还是意外)中潜在风险的认识。