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非处方止痛药的使用模式及公众认知:聚焦于非甾体抗炎药

Patterns of use and public perception of over-the-counter pain relievers: focus on nonsteroidal antiinflammatory drugs.

作者信息

Wilcox C Mel, Cryer Byron, Triadafilopoulos George

机构信息

Department of Medicine, Division of Gastroenterology, University of Alabama at Birmingham, Alabama 35294-0007, USA.

出版信息

J Rheumatol. 2005 Nov;32(11):2218-24.

PMID:16265706
Abstract

OBJECTIVE

To assess the frequency and indications for over-the-counter (OTC) nonsteroidal antiinflammatory drug (NSAID) use and to what degree the public is aware of their side effects.

METHODS

Two surveys totaling 9062 respondents were performed of the American public. The Roper survey, conducted in 1997, and the National Consumers League (NCL) survey, conducted in December 2002, were intended primarily to assess the public's use of and attitudes toward NSAID and OTC analgesics.

RESULTS

Ibuprofen based drugs were the most frequently used OTC in both surveys (57% Roper, 33% NCL). In the Roper survey, 17% of respondents used NSAID, with 38% using both prescription and OTC. Forty-six percent of exclusive OTC users believed OTC were safer, while 56% of exclusive users of prescription NSAID believed they were safer. Sixty percent and 29% of exclusive OTC users were neither aware of nor believed they were at risk for side effects from NSAID, respectively. Twenty-six percent of respondents used more than the recommended dose on the label, while 22% believed warning symptoms would always precede any NSAID induced complications. In the NCL survey, 83% had used an OTC agent in the last year, with 15% reporting daily use, and 49% were not concerned about potential side effects. In this survey, 30% believed there was less risk with OTC analgesics, and 44% consumed more than the recommended dosage on the label.

CONCLUSION

OTC analgesics including NSAID are widely used, are frequently taken inappropriately and potentially dangerously, and users are generally unaware of the potential for adverse side effects. Educational intervention directed toward both patients and physicians appears warranted.

摘要

目的

评估非处方(OTC)非甾体抗炎药(NSAID)的使用频率和适应症,以及公众对其副作用的知晓程度。

方法

对美国公众进行了两项总计9062名受访者的调查。1997年进行的罗珀调查和2002年12月进行的全国消费者联盟(NCL)调查,主要旨在评估公众对NSAID和OTC镇痛药的使用情况及态度。

结果

在两项调查中,布洛芬类药物都是使用最频繁的OTC药物(罗珀调查中占57%,NCL调查中占33%)。在罗珀调查中,17%的受访者使用NSAID,其中38%同时使用处方和OTC药物。46%的单纯OTC使用者认为OTC药物更安全,而56%的单纯处方NSAID使用者认为处方NSAID更安全。单纯OTC使用者中,分别有60%和29%既不知道也不认为自己有NSAID副作用风险。26%的受访者使用剂量超过标签推荐剂量,而22%的受访者认为警告症状总会先于任何NSAID引起的并发症出现。在NCL调查中,83%的人在过去一年使用过OTC药物,15%报告每日使用,49%的人不担心潜在副作用。在这项调查中,30%的人认为OTC镇痛药风险较小,44%的人服用剂量超过标签推荐剂量。

结论

包括NSAID在内的OTC镇痛药被广泛使用,但经常使用不当且可能存在危险,使用者通常未意识到潜在的不良副作用。针对患者和医生的教育干预似乎很有必要。

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