GATA-4、-5和-6在脊椎动物心脏发育中的作用。

The roles of GATA-4, -5 and -6 in vertebrate heart development.

作者信息

Peterkin Tessa, Gibson Abigail, Loose Matthew, Patient Roger

机构信息

Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS.

出版信息

Semin Cell Dev Biol. 2005 Feb;16(1):83-94. doi: 10.1016/j.semcdb.2004.10.003. Epub 2004 Dec 15.

DOI:10.1016/j.semcdb.2004.10.003

PMID:15659343

Abstract

The transcription factors GATA-4, -5 and -6 are expressed very early in heart tissue. Essential GATA sites have been detected in several cardiac genes and the cardiac GATA factors interact with a wide variety of cofactors which synergistically increase gene expression. These multi-protein transcriptional complexes confer promoter-specificity on the GATA factors and also on the more broadly expressed cofactors. Here we summarise the data on these interactions and represent the conclusions as a GATA factor-based genetic regulatory network for the heart. Of the three cardiac GATAs, GATA-4 is by far the most extensively studied, however, loss-of-function data question its presumed dominance during heart development as opposed to hypertrophy.

摘要

转录因子GATA-4、-5和-6在心脏组织中很早就开始表达。在多个心脏基因中已检测到关键的GATA位点，并且心脏GATA因子与多种辅因子相互作用，这些辅因子协同增加基因表达。这些多蛋白转录复合物赋予GATA因子以及更广泛表达的辅因子启动子特异性。在此，我们总结了关于这些相互作用的数据，并将结论表示为基于GATA因子的心脏遗传调控网络。在三种心脏GATA中，GATA-4是迄今为止研究最为广泛的，然而，功能丧失数据对其在心脏发育过程中相对于肥大过程中假定的主导地位提出了质疑。