Tak Paul P
Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, The Netherlands.
J Rheumatol Suppl. 2005 Jan;72:25-6.
The synovium is the key target of the disease process in rheumatoid arthritis (RA). Examination of synovial tissue samples may provide insight into the events that take place in different phases of the disease and may help to decipher the mechanism of action of antirheumatic treatment. This review describes the features of synovitis in early RA, which clearly represent chronic inflammation. There is marked interindividual variability, suggesting that RA consists of different pathogenetic subsets. Evaluation of serial synovial tissue samples has shown that effective treatment is associated with a reduction in synovial macrophages, independent of the specific mechanism of action of the compound. This suggests that these are key effector cells in the pathogenesis. In addition, it provides a biomarker that can be used in clinical trials.
滑膜是类风湿关节炎（RA）疾病进程的关键靶点。对滑膜组织样本的检查可能有助于深入了解疾病不同阶段所发生的事件，并有助于阐明抗风湿治疗的作用机制。本综述描述了早期RA滑膜炎的特征，其明显表现为慢性炎症。个体间存在显著差异，这表明RA由不同的致病亚群组成。对系列滑膜组织样本的评估表明，有效治疗与滑膜巨噬细胞数量减少有关，而与化合物的具体作用机制无关。这表明这些细胞是发病机制中的关键效应细胞。此外，它还提供了一种可用于临床试验的生物标志物。
