类风湿关节炎治疗的新方法：临床试验中滑膜生物标志物评估的经验教训。
Novel approaches for the treatment of rheumatoid arthritis: lessons from the evaluation of synovial biomarkers in clinical trials.
作者信息
Gerlag Daniëlle M, Tak Paul P
机构信息
Division of Clinical Immunology and Rheumatology, Academic Medical Centre/University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
出版信息
Best Pract Res Clin Rheumatol. 2008 Apr;22(2):311-23. doi: 10.1016/j.berh.2008.02.002.
PMID:18455687
Abstract
The analysis of synovial biomarkers is increasingly used in the context of innovative trial design in rheumatoid arthritis (RA). This approach, which is generally well tolerated by patients, has been used to provide insight into the pathogenesis of RA and the mechanism of action of therapy, as well as for screening purposes during early drug development.
摘要
滑膜生物标志物分析在类风湿关节炎（RA）创新试验设计中的应用越来越广泛。这种方法通常患者耐受性良好，已被用于深入了解RA的发病机制和治疗作用机制，以及在药物早期研发过程中用于筛选目的。
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