Sidransky D, Tokino T, Hamilton S R, Kinzler K W, Levin B, Frost P, Vogelstein B
Department of Oncology, Johns Hopkins University, Baltimore, MD 21231.
Science. 1992 Apr 3;256(5053):102-5. doi: 10.1126/science.1566048.
Colorectal (CR) tumors are usually curable if detected before metastasis. Because genetic alterations are associated with the development of these tumors, mutant genes may be found in the stool of individuals with CR neoplasms. The stools of nine patients whose tumors contained mutations of K-ras were analyzed. In eight of the nine cases, the ras mutations were detectable in DNA purified from the stool. These patients included those with benign and malignant neoplasms from proximal and distal colonic epithelium. Thus, colorectal tumors can be detected by a noninvasive method based on the molecular pathogenesis of the disease.
如果在转移前被发现，结直肠癌（CR）肿瘤通常是可治愈的。由于基因改变与这些肿瘤的发生发展相关，因此在患有CR肿瘤的个体粪便中可能会发现突变基因。对9例肿瘤含有K-ras突变的患者的粪便进行了分析。在这9例中的8例中，从粪便中纯化的DNA中可检测到ras突变。这些患者包括来自近端和远端结肠上皮的良性和恶性肿瘤患者。因此，基于该疾病的分子发病机制，可以通过非侵入性方法检测结直肠癌肿瘤。
