af Geijerstam J-L, Britton M
The Swedish Council on Technology Assessment in Health Care (SBU) and the Department of Medicine, Clinical Epidemiology Unit, Karolinska University Hospital, Stockholm, Sweden.
Emerg Med J. 2005 Feb;22(2):103-7. doi: 10.1136/emj.2004.015396.
To search the literature for case reports on adverse outcomes in patients with mild head injury where acute computed tomography (CT) findings had been normal.
Mild head injury was defined as head trauma involving amnesia or loss of consciousness, but where neurological findings are normal on arrival at hospital (GCS 15). The scientific literature was systematically searched for case reports where an early CT was normal and the patient deteriorated within two days. In these cases, early discharge despite a normal CT head scan would have been hazardous.
Two prospective studies were found that investigated the safety of early CT in 3300 patients with mild head injury, as were 39 reports on adverse outcomes describing 821 patients. In addition, 52 studies containing over 62 000 patients with mild head injury were reviewed. In total, only three cases were deemed to have experienced an early adverse outcome despite a normal CT and GCS 15 on initial presentation. In another eight cases with incomplete descriptions, the interpretation was doubtful. Many reports of complications were not relevant to our question and excluded. These reports included cases with more severe head injury/not GCS 15 at presentation, complications that occurred after more than two days, or initial CT findings that were not fully normal.
Very few cases were found where an early adverse event occurred after normal acute CT in patients with mild head injury. The strongest scientific evidence available at this time shows that a CT strategy is a safe way to triage patients for admission.
检索文献,查找轻度颅脑损伤患者急性计算机断层扫描(CT)结果正常但出现不良结局的病例报告。
轻度颅脑损伤定义为伴有失忆或意识丧失的头部外伤,但入院时神经系统检查结果正常(格拉斯哥昏迷量表[GCS]评分为15分)。系统检索科学文献,查找早期CT结果正常且患者在两天内病情恶化的病例报告。在这些病例中,尽管CT头部扫描结果正常但仍过早出院可能会带来危险。
发现两项前瞻性研究调查了3300例轻度颅脑损伤患者早期CT检查的安全性,还发现39篇关于不良结局的报告,描述了821例患者。此外,还回顾了52项包含超过62000例轻度颅脑损伤患者的研究。总共只有3例被认为尽管初次就诊时CT结果正常且GCS评分为15分,但仍出现了早期不良结局。另有8例描述不完整的病例,其解读存在疑问。许多并发症报告与我们的问题无关,予以排除。这些报告包括就诊时颅脑损伤更严重/GCS评分不为15分的病例、两天后出现的并发症,或初始CT结果不完全正常的病例。
很少发现轻度颅脑损伤患者急性CT结果正常后出现早期不良事件的病例。目前可得的最有力科学证据表明,CT检查策略是对患者进行入院分类的安全方法。