Salonia Andrea, Nappi Rossella E, Pontillo Marina, Daverio Rita, Smeraldi Antonella, Briganti Alberto, Fabbri Fabio, Zanni Giuseppe, Rigatti Patrizio, Montorsi Francesco
Department of Urology, University Vita-Salute San Raffaele, Milan, Italy.
Horm Behav. 2005 Feb;47(2):164-9. doi: 10.1016/j.yhbeh.2004.10.002. Epub 2004 Dec 9.
Circulating levels of the neuro-hypophysial nonapeptide oxytocin increase during sexual arousal and orgasm in both men and women. A few studies have evaluated the effect of the menstrual cycle on plasma oxytocin in normally cycling, sexually active, healthy fertile women using or not using contraceptive pills. In 20 ovulating women and 10 women taking an oral contraceptive (group 1 and group 2, respectively), sexual function, hormonal profile, and plasma oxytocin (OT) were evaluated throughout the menstrual cycle. In group 1, plasma OT was significantly lower during the luteal phase in comparison with both the follicular and ovulatory phases. Plasma oxytocin was significantly correlated with the lubrication domain of the Female Sexual Function Index (FSFI) during the luteal phase and showed a trend towards statistical significance during the follicular phase. In group 2, plasma OT did not show any significant fluctuation throughout the menstrual cycle, even though a significant correlation was evident with both the arousal and the lubrication domain of the FSFI during the assumption of the contraceptive pill. These findings suggest that plasma OT fluctuates throughout the menstrual cycle in normally cycling healthy fertile women with adequate sexual activity but not taking any oral contraceptive pill. Moreover, plasma OT levels significantly relates to the genital lubrication in both women taking and not taking oral contraceptive pill apparently confirming its role in peripheral activation of sexual function.
神经垂体九肽催产素的循环水平在男性和女性性唤起及性高潮期间都会升高。一些研究评估了月经周期对正常月经周期、性活跃、健康可育女性（无论是否服用避孕药）血浆催产素的影响。对20名处于排卵期的女性和10名服用口服避孕药的女性（分别为第1组和第2组）在整个月经周期中进行了性功能、激素水平和血浆催产素（OT）评估。在第1组中，黄体期的血浆OT水平显著低于卵泡期和排卵期。黄体期血浆催产素与女性性功能指数（FSFI）的润滑领域显著相关，在卵泡期有统计学意义的趋势。在第2组中，血浆OT在整个月经周期中未显示出任何显著波动，尽管在服用避孕药期间与FSFI的唤起和润滑领域均存在显著相关性。这些发现表明，在正常月经周期、有足够性活动但未服用任何口服避孕药的健康可育女性中，血浆OT在整个月经周期中会波动。此外，无论服用还是未服用口服避孕药的女性，血浆OT水平均与生殖器润滑显著相关，这显然证实了其在性功能外周激活中的作用。
