复苏钠电流的分子机制得以揭示。
The molecular machinery of resurgent sodium current revealed.
作者信息
Bean Bruce P
机构信息
Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
出版信息
Neuron. 2005 Jan 20;45(2):185-7. doi: 10.1016/j.neuron.2005.01.006.
PMID:15664169
Abstract
Some TTX-sensitive sodium channels open transiently during recovery from inactivation, generating a "resurgent" sodium current that flows immediately following action potentials. In this issue of Neuron, Grieco and colleagues present evidence that resurgent sodium current results from a novel form of inactivation in which the cytoplasmic tail of the beta4 subunit acts as a classic open-channel blocker.
摘要
一些对河豚毒素敏感的钠通道在从失活状态恢复过程中短暂开放，产生一种“复苏”钠电流，该电流在动作电位之后立即流动。在本期《神经元》杂志中，格里eco及其同事提供证据表明，复苏钠电流源自一种新的失活形式，其中β4亚基的胞质尾部充当经典的开放通道阻滞剂。
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