Singh Devinder, Chander Vikas, Chopra Kanwaljit
Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India.
Toxicology. 2005 Feb 28;207(3):339-47. doi: 10.1016/j.tox.2004.09.018.
Renal ischemia followed by reperfusion leads to acute renal failure in both native kidneys and renal allografts. Cyclosporine A (CsA) has been used as an immunosuppressive agent in organ transplantation. In the present study, the effect of CsA on ischemia/reperfusion (I/R)-induced injury in the kidney was investigated. Ischemia/reperfusion injury caused a significant deterioration in the renal function, morphology and gave rise to a severe oxidative stress in the kidney. At 3 mg/kg i.v., CsA significantly improved the functional and histological parameters and attenuated the oxidative stress induced by renal ischemia/reperfusion. From the results of our study, it can be concluded that low-dose CsA pretreatment preconditions the rat kidneys against subsequent ischemia/reperfusion injury.
肾缺血再灌注会导致自体肾和肾移植受者的急性肾衰竭。环孢素A（CsA）已被用作器官移植中的免疫抑制剂。在本研究中，研究了CsA对肾脏缺血/再灌注（I/R）诱导损伤的影响。缺血/再灌注损伤导致肾功能、形态显著恶化，并在肾脏中引发严重的氧化应激。静脉注射3mg/kg的CsA可显著改善功能和组织学参数，并减轻肾缺血/再灌注诱导的氧化应激。从我们的研究结果可以得出结论，低剂量CsA预处理可使大鼠肾脏对随后的缺血/再灌注损伤产生预处理作用。
