Miño J, Muschietti L, Ferraro G, Martino V, Acevedo C
Cátedra de Farmacología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956 (1113), Buenos Aires, Argentina.
Fitoterapia. 2005 Jan;76(1):100-3. doi: 10.1016/j.fitote.2004.10.009.
The antinociceptive properties of the aqueous extract of Eupatorium buniifolium aerial parts were investigated in chemical and thermal models of nociception in mice. Oral doses of 250 and 500 mg/kg produced an inhibition of 42.3% and 73.9%, respectively, of the abdominal writhes induced by acetic acid in mice. This antinociceptive effect was not reversed by pretreatment with naloxone. In the formalin test, the administration of 500 and 1000 mg/kg p.o. had no effects in the first phase (0-5 min) but produced a dose-dependent analgesic effect on the second phase (15-30 min) with inhibitions of the licking time of 38.9% and 57.3%, respectively. In the hot plate test, no effect was seen at the dose of 500 mg/kg p.o.
在小鼠伤害感受的化学和热模型中，对野马追地上部分水提取物的抗伤害感受特性进行了研究。口服剂量为250和500 mg/kg时，分别对小鼠由乙酸诱导的腹部扭体产生了42.3%和73.9%的抑制作用。这种抗伤害感受作用不会因用纳洛酮预处理而逆转。在福尔马林试验中，口服500和1000 mg/kg在第一阶段（0 - 5分钟）没有作用，但在第二阶段（15 - 30分钟）产生了剂量依赖性镇痛作用，舔舐时间的抑制率分别为38.9%和57.3%。在热板试验中，口服500 mg/kg剂量时未见效果。
