Santos Thiago C, Marques Maxsuel S, Menezes Igor A C, Dias Kellyane S, Silva Aline B L, Mello Iderjane C M, Carvalho Ana C S, Cavalcanti Sócrates C H, Antoniolli Angelo R, Marçal Rosilene M
Department of Physiology, Faculty of Pharmaceutical Sciences, Federal University of Sergipe, São Cristovão, Brazil.
Fitoterapia. 2007 Jul;78(5):333-6. doi: 10.1016/j.fitote.2007.01.006. Epub 2007 Apr 11.
The aqueous extract of Hyptis suaveolens leaves was studied for their antinociceptive property in chemical and thermal models of nociception in mice. Oral administration of the aqueous extract (100, 200, and 400 mg/kg) dose-dependently reduced the number of writhings induced by acetic acid, decreased the licking activity of the early phase in formalin test and increased the reaction time in hot-plate test. The antinociceptive effect was significantly antagonized by naloxone (3 mg/kg; i.p.). Preliminary acute toxicity study showed that no animal death with doses up to 5 g/kg (p.o.).
研究了香蜂草叶水提取物在小鼠化学性和热性伤害感受模型中的抗伤害感受特性。口服水提取物（100、200和400 mg/kg）剂量依赖性地减少了乙酸诱导的扭体次数，降低了福尔马林试验早期阶段的舔舐活性，并增加了热板试验中的反应时间。纳洛酮（3 mg/kg；腹腔注射）可显著拮抗这种抗伤害感受作用。初步急性毒性研究表明，口服剂量高达5 g/kg时无动物死亡。
