Hurme M, Lehtimäki T, Jylhä M, Karhunen P J, Hervonen A
Department of Microbiology and Immunology, University of Tampere Medical School, Tampere University Hospital, FIN-33014, Tampere, Finland.
Mech Ageing Dev. 2005 Mar;126(3):417-8. doi: 10.1016/j.mad.2004.10.001.
Increased rate of inflammation has been observed to be associated with aging. This is manifested, e.g. as increased blood levels of proinflammatory cytokines, such as interleukin-6 (IL-6). The production of IL-6 is, at least partially, genetically determined the single nucleotide polymorphism (SNP) at the promoter (-174G/C) being decisive. Consequently, some studies have demonstrated that the -174G/C genotype frequencies are different in very old persons as compared to younger ones. However, the results published this far have been conflicting. One of the main confounding factors in these kind of case/control association studies is the undetected difference in the population structure. To avoid this, we now have collected the mortality data of our cohort of 285 nonagenarians (representing mortality between 90 and 95 years of age) and correlated these to the IL-6 genotype. The frequency of -174 allele G was clearly higher in the survivors (n = 114) than in the non-survivors (n = 171).
炎症发生率升高与衰老有关。这表现为，例如促炎细胞因子（如白细胞介素 - 6，IL - 6）的血液水平升高。IL - 6的产生至少部分由基因决定，启动子处的单核苷酸多态性（SNP）（-174G/C）起决定性作用。因此，一些研究表明，与年轻人相比，非常年长者中 -174G/C基因型频率不同。然而，到目前为止发表的结果相互矛盾。这类病例/对照关联研究中的一个主要混杂因素是人群结构中未被检测到的差异。为避免这种情况，我们现在收集了我们285名九旬老人队列的死亡率数据（代表90至95岁之间的死亡率），并将这些数据与IL - 6基因型相关联。-174等位基因G在幸存者（n = 114）中的频率明显高于非幸存者（n = 171）。
