白细胞介素-6 -174G/C启动子多态性与南印度女性子宫内膜异位症无关。
The interleukin-6 -174G/C promoter polymorphism is not associated with endometriosis in South Indian women.
作者信息
Bhanoori Manjula, Babu Kusuma Arvind, Deenadayal Mamata, Kennedy Stephen, Shivaji Sisinthy
机构信息
Centre for Cellular and Molecular Biology, Hyderabad, India.
出版信息
J Soc Gynecol Investig. 2005 Jul;12(5):365-9. doi: 10.1016/j.jsgi.2005.03.005.
OBJECTIVE
To investigate the association of the -174 G/C promoter polymorphism of the interleukin-6 (IL-6) gene with endometriosis in South Indian women.
METHODS
The genotype frequencies of the common IL-6 -174 G/C polymorphism were compared in infertility patients with (n = 232) and without (n = 210) endometriosis using polymerase chain reaction (PCR) and sequencing analysis.
RESULTS
The genotype frequencies among the cases and controls were G/G 62.9% and 71.9%, G/C 34.1% and 25.2%, and C/C 3.0% and 2.9%. The G and C allele frequencies were 80% and 84.6%, and 20% and 15.4%, respectively. There were no statistically significant differences in the genotype distributions or allele frequencies between the cases and controls (P = .12).
CONCLUSIONS
The present study demonstrates no significant association between the IL-6 -174 G/C promoter polymorphism and endometriosis in South Indian women.
目的
研究白介素-6（IL-6）基因-174 G/C启动子多态性与南印度女性子宫内膜异位症之间的关联。
方法
采用聚合酶链反应（PCR）和测序分析，比较患有（n = 232）和未患有（n = 210）子宫内膜异位症的不孕患者中常见的IL-6 -174 G/C多态性的基因型频率。
结果
病例组和对照组的基因型频率分别为：G/G 62.9%和71.9%，G/C 34.1%和25.2%，C/C 3.0%和2.9%。G和C等位基因频率分别为80%和84.6%，以及20%和15.4%。病例组和对照组之间的基因型分布或等位基因频率无统计学显著差异（P = 0.12）。
结论
本研究表明，IL-6 -174 G/C启动子多态性与南印度女性子宫内膜异位症之间无显著关联。
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