Williams Wendol, Reimold Matthias, Kerich Michael, Hommer Dan, Bauer Michael, Heinz Andreas
National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.
Psychiatry Res. 2004 Dec 30;132(3):219-24. doi: 10.1016/j.pscychresns.2004.07.004.
We measured the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) in cerebrospinal fluid (CSF), regional cerebral glucose uptake (rCMRglc) as assessed with positron emission tomography in the medial prefrontal cortex (PFC) and severity of clinical depression (Beck's Depression Inventory, BDI) in detoxified male alcoholics and age-matched healthy men. In alcoholics, the severity of clinical depression was negatively correlated with rCMRglc in the medial PFC and positively with CSF 5-HIAA concentrations. A voxel-based analysis showed that the strongest correlation between CSF 5-HIAA levels and rCMRglc was found in alcoholics in the left orbitofrontal and medial PFC (BA10 and BA11); no significant correlations were observed among healthy control subjects. This pilot study indicates that a dysfunction of medial PFC may interact with central serotonin turnover and negative mood states during early abstinence.
我们测量了戒酒后男性酗酒者和年龄匹配的健康男性脑脊液（CSF）中的血清素代谢物5-羟吲哚乙酸（5-HIAA）、通过正电子发射断层扫描评估的内侧前额叶皮质（PFC）区域脑葡萄糖摄取（rCMRglc）以及临床抑郁症的严重程度（贝克抑郁量表，BDI）。在酗酒者中，临床抑郁症的严重程度与内侧PFC中的rCMRglc呈负相关，与CSF 5-HIAA浓度呈正相关。基于体素的分析表明，在酗酒者的左侧眶额和内侧PFC（BA10和BA11）中发现CSF 5-HIAA水平与rCMRglc之间的相关性最强；在健康对照受试者中未观察到显著相关性。这项初步研究表明，内侧PFC功能障碍可能在早期戒酒期间与中枢血清素代谢和负面情绪状态相互作用。
