Fujimoto Toshiro, Takeuchi Kouzou, Matsumoto Tetsuro, Fujita Seigo, Honda Kenichi, Higashi Yuji, Kato Nobumasa
Department Psychiatry of Faculty of Medicine of University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Psychiatry Res. 2008 Oct 30;164(1):48-57. doi: 10.1016/j.pscychresns.2007.03.010. Epub 2008 Sep 18.
Positron emission tomography (PET) with fluorodeoxyglucose-F18 was used to examine glucose metabolism in patients with late-onset major depression, all hospitalized non-responders to antidepressant medication. The three-dimensional stereotactic surface projection (3D-SSP) method provided 3D-SSP images and relative metabolic values with minimal partial volume effects. The 3D-SSP score map showed decreased relative metabolism in the prefontal, cingulate and parietal regions in both hemispheres, and in the temporal region on the right, and increased relative metabolism in the occipital pole, vermis, cerebellum, dorsal-frontal, central convexity areas and basal ganglia in both hemispheres in patients compared with controls. The ratio of the parietal to occipital values in right plus left hemispheres was significantly decreased. Correlation coefficients of the anterior cingulate-primary sensorimotor, posterior cingulate-primary sensorimotor and occipital-media frontal in both hemispheres, of the frontal-primary sensorimotor, occipital-parahippocampal, primary visual-medial frontal and parahippocampal-amygdala in the right, and the frontal-vermis, parietal-thalamus, temporal-vermis, occipital-putamen, primary visual-putamen, thalamus-vermis and thalamus-cerebellum in the left were significantly different in patients compared with controls. Patients with late-onset depression who were treatment non-responders showed alterations not only in limbic-cortical circuits, but also in a wider network of thalamo-cortical circuits.
采用氟代脱氧葡萄糖-F18正电子发射断层扫描（PET）技术，对晚发性重度抑郁症患者（所有患者均为住院治疗且对抗抑郁药物无反应者）的葡萄糖代谢情况进行检查。三维立体定向表面投影（3D-SSP）方法可提供具有最小部分容积效应的3D-SSP图像和相对代谢值。3D-SSP评分图显示，与对照组相比，患者双侧前额叶、扣带回和顶叶区域以及右侧颞叶区域的相对代谢降低，而双侧枕极、小脑蚓部、小脑、背侧额叶、中央凸面区域和基底神经节的相对代谢增加。左右半球顶叶与枕叶值的比率显著降低。患者与对照组相比，双侧前扣带回-初级感觉运动区、后扣带回-初级感觉运动区和枕叶-内侧额叶之间，右侧额叶-初级感觉运动区、枕叶-海马旁回、初级视觉-内侧额叶和海马旁回-杏仁核之间，以及左侧额叶-小脑蚓部、顶叶-丘脑、颞叶-小脑蚓部、枕叶-壳核、初级视觉-壳核、丘脑-小脑蚓部和丘脑-小脑之间的相关系数存在显著差异。对抗抑郁治疗无反应的晚发性抑郁症患者不仅边缘-皮质回路存在改变，而且丘脑-皮质回路的更广泛网络也存在改变。
