Cami-Kobeci Gerta, Slatford Paul A, Whittlesey Michael K, Williams Jonathan M J
Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK.
Bioorg Med Chem Lett. 2005 Feb 1;15(3):535-7. doi: 10.1016/j.bmcl.2004.11.050.
A clean and efficient method for the N-alkylation of tryptamine and phenethylamine, employing alcohols as the alkylating agents, has been developed. The reaction proceeds via catalytic electronic activation, involving an iridium catalyst which activates the alcohol by borrowing hydrogen from the substrate, returning it later in the catalytic cycle. Some examples of N-heterocyclisation have been performed employing a diol as the substrate.
已开发出一种以醇类作为烷基化试剂，用于色胺和苯乙胺N-烷基化的清洁高效方法。该反应通过催化电子活化进行，涉及一种铱催化剂，它通过从底物中借氢来活化醇类，并在催化循环后期将氢返还。已使用二醇作为底物进行了一些N-杂环化的实例。
