恶性疟原虫裂殖子表面蛋白6展现出多个天然存在抗体的靶点，这些抗体介导单核细胞依赖的寄生虫杀伤作用。
Plasmodium falciparum merozoite surface protein 6 displays multiple targets for naturally occurring antibodies that mediate monocyte-dependent parasite killing.
作者信息
Singh Subhash, Soe Soe, Roussilhon Christian, Corradin Giampietro, Druilhe Pierre
机构信息
Bio-medical Parasitology Unit, Institute Pasteur, 28 rue du Dr Roux, 75015 Paris, France.
出版信息
Infect Immun. 2005 Feb;73(2):1235-8. doi: 10.1128/IAI.73.2.1235-1238.2005.
Abstract
Plasmodium falciparum MSP6 is a merozoite surface antigen that shows organization and sequence homologies similar to those of MSP3. Within its C-terminus conserved region, it presents some epitopes that are cross-reactive with MSP3 and others that are not, both being targets of naturally occurring antibodies that block the P. falciparum erythrocytic cycle in cooperation with monocytes.
摘要
恶性疟原虫MSP6是一种裂殖子表面抗原，其结构和序列同源性与MSP3相似。在其C端保守区域内，它呈现出一些与MSP3交叉反应的表位和其他不交叉反应的表位，二者都是天然存在的抗体的靶点，这些抗体与单核细胞协同作用可阻断恶性疟原虫的红细胞内周期。
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