Chebbi A, Bouguila H, Boussaid S, Ben Aleya N, Zgholi H, Malek I, Zeghal I, Nacef L
Department A of ophthalmology, Hedi Rais institute of ophthalmology, boulevard 9-Avril, 1006 Bab Saadoun, Tunis, Tunisie.
Department A of ophthalmology, Hedi Rais institute of ophthalmology, boulevard 9-Avril, 1006 Bab Saadoun, Tunis, Tunisie.
J Fr Ophtalmol. 2014 Jun;37(6):442-8. doi: 10.1016/j.jfo.2014.01.009. Epub 2014 May 1.
To report the relative frequency of presenting signs in Tunisian children with retinoblastoma and to evaluate their prognostic impact.
A retrospective study was undertaken of 200 patients with retinoblastoma examined and treated between January 1993 and June 2009.
There were 123 boys and 77 girls. For all cases, mean age at diagnosis was 29.8 months (range, 1 month to 9 years). There were 138 (69%) unilateral cases and 62 (31%) bilateral cases. Nineteen children (9.5%) had a family history of retinoblastoma. The most common signs were leukocoria (80%) and strabismus (28%) followed by proptosis. Orbital inflammation, hyphemia and phthisis are rare presenting findings in retinoblastoma. In our series, 26 children (13%) presented with extraocular retinoblastoma. Leukocoria and proptosis are significantly associated with a worse prognosis.
The ability to recognize the presenting signs and symptoms of retinoblastoma can lead to earlier diagnosis and better prognosis.
报告突尼斯视网膜母细胞瘤患儿出现症状的相对频率，并评估其对预后的影响。
对1993年1月至2009年6月期间接受检查和治疗的200例视网膜母细胞瘤患者进行回顾性研究。
其中男孩123例，女孩77例。所有病例的诊断平均年龄为29.8个月（范围1个月至9岁）。单侧病例138例（69%），双侧病例62例（31%）。19名儿童（9.5%）有视网膜母细胞瘤家族史。最常见的症状是白瞳症（80%）和斜视（28%），其次是眼球突出。眼眶炎症、前房积血和眼球痨是视网膜母细胞瘤罕见的表现。在我们的系列研究中，26名儿童（13%）表现为眼外视网膜母细胞瘤。白瞳症和眼球突出与较差的预后显著相关。
识别视网膜母细胞瘤的症状和体征有助于早期诊断并改善预后。
