早产合并妊娠时母体血浆促肾上腺皮质激素释放激素水平升高。
Elevated maternal plasma corticotropin-releasing hormone levels in pregnancies complicated by preterm labor.
作者信息
Warren W B, Patrick S L, Goland R S
机构信息
Department of Obstetrics and Gynecology, Columbia University, College of Physicians and Surgeons, New York, NY 10032.
出版信息
Am J Obstet Gynecol. 1992 Apr;166(4):1198-204; discussion 1204-7. doi: 10.1016/s0002-9378(11)90606-1.
OBJECTIVES
We investigated whether maternal plasma levels of the placental hormone corticotropin-releasing hormone are elevated in pregnancies complicated by preterm labor.
STUDY DESIGN
Mean maternal corticotropin-releasing hormone levels were studied in women who met specific criteria for preterm labor and in women with normal pregnancies. Levels were also compared in the latent and active phases during term labor.
RESULTS
In pregnancies complicated by preterm labor, maternal corticotropin-releasing hormone levels were higher than in normal pregnancies; this elevation occurred before labor was diagnosed clinically (p less than 0.05). When preterm labor was associated with infection, the mean levels were not elevated. Mean plasma levels were similar in latent and active phases during labor at term.
CONCLUSION
Maternal plasma corticotropin-releasing hormone levels are elevated in association with preterm labor. This elevation does not appear to be due to labor itself and may reflect an early activation of the placenta before the onset of preterm labor.
目的
我们研究了在并发早产的妊娠中，母体血浆中胎盘激素促肾上腺皮质激素释放激素水平是否升高。
研究设计
对符合早产特定标准的女性以及正常妊娠女性的母体促肾上腺皮质激素释放激素平均水平进行了研究。还对足月分娩潜伏期和活跃期的水平进行了比较。
结果
在并发早产的妊娠中，母体促肾上腺皮质激素释放激素水平高于正常妊娠；这种升高在临床诊断出早产之前就已出现（p<0.05）。当早产与感染相关时，平均水平未升高。足月分娩时潜伏期和活跃期的平均血浆水平相似。
结论
母体血浆促肾上腺皮质激素释放激素水平与早产相关升高。这种升高似乎并非由分娩本身引起，可能反映了早产发作前胎盘的早期激活。
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