Sarchielli Paola, Tarducci Roberto, Presciutti Otello, Gobbi Gianni, Pelliccioli Gian Piero, Stipa Giuseppe, Alberti Andrea, Capocchi Giuseppe
Neuroscience Department, University of Perugia, Policlinico Monteluce, Via E Dal Pozzo, 06126 Perugia, Italy.
Neuroimage. 2005 Feb 15;24(4):1025-31. doi: 10.1016/j.neuroimage.2004.11.005. Epub 2005 Jan 5.
The present study was aimed at investigating changes in brain metabolites due to visual cortex activation in migraineurs and normal subjects by (1)H-magnetic resonance spectroscopy (MRS). Twenty-two migraine patients with aura, 22 migraine patients without aura, and 10 control subjects were assessed. The volume of interest (about 8 cm(3)) was placed on the visual cortex area and the visual stimulus was applied using MR-compatible goggles with a flashing red light at a frequency of 8 Hz and an intensity of 14 lx. Data were acquired over 36'40". The experimental time course was: baseline phase, from 0 to 3'40" (1 spectrum); on phase (flashing light condition), from 3'40" to 29'20" (1540") (7 spectra), and off phase, from 29'20" to the end of the experiment at 36'40" (2 spectra). The main result of photic stimulation in patients with migraine with aura is the more consistent decrease (-14.61%) of the N-acetylaspartate (NAA) signal, which is significantly greater than that found in migraine patients without aura and control subjects. A parallel slight increase in the lactate peak was also detected. The above findings support little differences in brain metabolites between the two patient groups assessed in interictal periods, which suggests a less efficient mitochondrial functioning in migraine with aura patients.
本研究旨在通过氢磁共振波谱（(1)H-MRS）研究偏头痛患者和正常受试者视觉皮层激活引起的脑代谢物变化。对22名有先兆偏头痛患者、22名无先兆偏头痛患者和10名对照受试者进行了评估。将感兴趣区域（约8 cm(3)）置于视觉皮层区域，并使用与磁共振兼容的护目镜施加视觉刺激，护目镜发出频率为8 Hz、强度为14 lx的闪烁红灯。数据采集时间为36分40秒。实验时间进程为：基线期，从0到3分40秒（1个谱）；开启期（闪烁光条件下），从3分40秒到29分20秒（1540秒）（7个谱），以及关闭期，从29分20秒到实验结束时的36分40秒（2个谱）。有先兆偏头痛患者光刺激的主要结果是N-乙酰天门冬氨酸（NAA）信号更一致地下降（-14.61%），这明显大于无先兆偏头痛患者和对照受试者中发现的下降幅度。还检测到乳酸峰同时略有增加。上述发现支持在发作间期评估的两组患者之间脑代谢物差异不大，这表明有先兆偏头痛患者的线粒体功能效率较低。
