Kalus Peter, Slotboom Johannes, Gallinat Jürgen, Federspiel Andrea, Gralla Jan, Remonda Luca, Strik Werner K, Schroth Gerhard, Kiefer Claus
Clinic for Psychiatry and Psychotherapy, Charité University Medicine, Campus Mitte, Turmstrasse 21, D-10559 Berlin, Germany.
Neuroimage. 2005 Feb 15;24(4):1122-9. doi: 10.1016/j.neuroimage.2004.10.007. Epub 2004 Dec 9.
Postmortem examinations and magnetic resonance imaging (MRI) studies suggest involvement of the entorhinal cortex (EC) in schizophrenic psychoses. However, the extent and nature of the possible pathogenetical process underlying the observed alterations of this limbic key region for processing of multimodal sensory information remains unclear. Three-dimensional high-resolution MRI volumetry and evaluation of the regional diffusional anisotropy based on diffusion tensor imaging (DTI) were performed on the EC of 15 paranoid schizophrenic patients and 15 closely matched control subjects. In schizophrenic patients, EC volumes showed a slight, but not significant, decrease. However, the anisotropy values, expressed as inter-voxel coherences (COH), were found to be significantly decreased by 17.9% (right side) and 12.5% (left side), respectively, in schizophrenics. Reduction of entorhinal diffusional anisotropy can be hypothesized to be functionally related to disturbances in the perforant path, the principal efferent EC fiber tract supplying the limbic system with neuronal input from multimodal association centers. Combinations of different MRI modalities are a promising approach for the detection and characterization of subtle brain tissue alterations.
尸检和磁共振成像（MRI）研究表明，内嗅皮质（EC）参与了精神分裂症性精神病。然而，这个用于处理多模态感觉信息的边缘关键区域所观察到的改变背后可能的致病过程的程度和性质仍不清楚。对15例偏执型精神分裂症患者和15例紧密匹配的对照者的内嗅皮质进行了三维高分辨率MRI容积测量以及基于扩散张量成像（DTI）的区域扩散各向异性评估。在精神分裂症患者中，内嗅皮质体积有轻微但不显著的减小。然而，发现精神分裂症患者的各向异性值，以体素间相干性（COH）表示，右侧和左侧分别显著降低了17.9%和12.5%。可以推测，内嗅皮质扩散各向异性的降低在功能上与穿通通路的紊乱有关，穿通通路是内嗅皮质的主要传出纤维束，为边缘系统提供来自多模态联合中枢的神经元输入。不同MRI模态的组合是检测和表征细微脑组织改变的一种有前景的方法。
