Kondo Yumiko, Suzuki Maki, Mugikura Shunji, Abe Nobuhito, Takahashi Shoki, Iijima Toshio, Fujii Toshikatsu
Division of Systems Neuroscience, Department of Developmental Biology and Neurosciences, Tohoku University Graduate School of Life Sciences, Sendai, Japan.
Neuroimage. 2005 Feb 15;24(4):1154-63. doi: 10.1016/j.neuroimage.2004.10.033. Epub 2004 Dec 19.
It has been confirmed that some kinds of what are called memory strategies dramatically improve the performance of memory recall. However, there has been no direct research to examine changes in brain activity associated with the use of the method of loci within individuals. In the present study, using fMRI, we compared brain activations before and after instruction in the method of loci during both the encoding and recall phases. The resulting behavioral data showed that the use of the method of loci significantly increased scores for memory recall. The imaging data showed that encoding after instruction in the method of loci, relative to encoding before it, was associated with signal increases in the right inferior frontal gyrus, bilateral middle frontal gyrus, left fusiform gyrus, and bilateral lingual gyrus/posterior cingulate gyrus. Comparison of recall after instruction in the method of loci with that before it showed significant activation in the left parahippocampal gyrus/retrosplenial cortex/cingulate gyrus/lingual gyrus, left precuneus, left fusiform gyrus, and right lingual gyrus/cingulate gyrus. The present study demonstrated the changes in brain activation pattern associated with the use of the method of loci; left fusiform and lingual activity was associated with both the encoding and recall phases, bilateral prefrontal activity with the encoding phase, and activity of the posterior part of the parahippocampal gyrus, retrosplenial cortex, and precuneus with the recall phase. These findings suggest that brain networks mediating episodic encoding and retrieval vary with how individuals encode the same stimuli.
已经证实，某些所谓的记忆策略能显著提高记忆回忆的表现。然而，尚未有直接研究来考察个体使用位置记忆法时大脑活动的变化。在本研究中，我们使用功能磁共振成像（fMRI），比较了在编码和回忆阶段接受位置记忆法指导前后的大脑激活情况。所得行为数据表明，使用位置记忆法显著提高了记忆回忆分数。成像数据显示，接受位置记忆法指导后的编码，相对于指导前的编码，与右侧额下回、双侧额中回、左侧梭状回以及双侧舌回/后扣带回的信号增强有关。将接受位置记忆法指导后的回忆与指导前的回忆进行比较，结果显示左侧海马旁回/压后皮质/扣带回/舌回、左侧楔前叶、左侧梭状回以及右侧舌回/扣带回有显著激活。本研究证明了与使用位置记忆法相关的大脑激活模式变化；左侧梭状回和舌回的活动与编码和回忆阶段均有关，双侧前额叶活动与编码阶段有关，海马旁回后部、压后皮质和楔前叶的活动与回忆阶段有关。这些发现表明，介导情景编码和检索的大脑网络会因个体对相同刺激的编码方式不同而有所变化。
