Lemaître Hervé, Crivello Fabrice, Dufouil Carole, Grassiot Blandine, Tzourio Christophe, Alpérovitch Annick, Mazoyer Bernard
Groupe d'Imagerie Neurofonctionnelle, UMR 6194, CNRS, CEA, Universités de Caen and Paris 5, GIP Cyceron, Boulevard Becquerel BP5229, F-14074 Caen, France.
Neuroimage. 2005 Feb 15;24(4):1205-13. doi: 10.1016/j.neuroimage.2004.10.016. Epub 2004 Dec 10.
The effect of ApoE genotype on grey matter (GM) atrophy was studied on a cohort of 750 healthy elderly volunteers (age range 63-75 years). High-resolution T1-weighted MR images were processed using both voxel-based morphometry and region of interest analysis for hippocampal volume estimation. Significant decrease of grey matter in epsilon(4) homozygous subjects (n = 12), as compared both to epsilon(4) heterozygous subjects (n = 175) and to noncarrier (n = 563) subjects, was found bilaterally in the medial temporal lobe, including the hippocampus, and extending over the superior temporal gyrus. By contrast, no significant difference was observed between epsilon(4) heterozygous subjects and noncarriers at the level of the medial temporal lobe. Follow-up of the cohort cognitive performances over 4 years after their MRI exam revealed that, as compared to noncarrier subjects, the relative risk of cognitive impairment was 5.9 for epsilon(4) homozygous subjects (P = 0.03), while it was not different from 1 for epsilon(4) heterozygous subjects (P = 0.92). These findings indicate that, in the age range of this cohort, ApoE-4 effects on cortical atrophy and cognitive performances of healthy elderly are limited to epsilon(4) homozygous subjects.
在一个由750名健康老年志愿者（年龄范围63 - 75岁）组成的队列中，研究了载脂蛋白E（ApoE）基因型对灰质（GM）萎缩的影响。使用基于体素的形态测量法和感兴趣区域分析对高分辨率T1加权磁共振图像进行处理，以估计海马体积。与ε(4)杂合子受试者（n = 175）和非携带者（n = 563）相比，在ε(4)纯合子受试者（n = 12）中，双侧内侧颞叶（包括海马体）的灰质显著减少，并延伸至上颞回。相比之下，在内侧颞叶水平，ε(4)杂合子受试者和非携带者之间未观察到显著差异。对该队列在MRI检查后4年的认知表现进行随访发现，与非携带者相比，ε(4)纯合子受试者认知障碍的相对风险为5.9（P = 0.03），而ε(4)杂合子受试者的相对风险与1无差异（P = 0.92）。这些发现表明，在该队列的年龄范围内，ApoE - 4对健康老年人皮质萎缩和认知表现的影响仅限于ε(4)纯合子受试者。
