白喉类毒素对初始长期受保护个体的短期增强作用。

Short-term booster effect of diphtheria toxoid in initially long-term protected individuals.

作者信息

Danilova Elena, Shiryayev Alexey, Skogen Vegard, Kristoffersen Einar Klaeboe, Sjursen Haakon

机构信息

Institute of Medicine, Centre for International Health, University of Bergen, Norway.

出版信息

Vaccine. 2005 Feb 10;23(12):1446-50. doi: 10.1016/j.vaccine.2004.09.020.

DOI:10.1016/j.vaccine.2004.09.020

PMID:15670879

Abstract

The main objective of this study was to investigate the booster antibody response in individuals with initially high levels of diphtheria antitoxin. Sixty individuals eligible for the routine booster by the age of 18 years each received a single dose of 5 Lf of diphtheria toxoid in diphtheria-tetanus vaccine. A double antigen ELISA was used for the assessment of the antibody levels. Chaotropic disruption in paired ELISA was used to test antibody avidity. The ratio between initial and maximum antibody concentrations after 1 month was >10 times higher and after 6 months still four times higher in those with initial antibody levels <1 IU/ml. In individuals with initial antibody levels >/=1 IU/ml a two-fold decrease was observed after 6 months compared to the initial levels. Thus, vaccination of individuals with initial long-term protection against diphtheria (antibody levels >/=1 IU/ml) is unnecessary and should be avoided.

摘要

本研究的主要目的是调查初始白喉抗毒素水平较高的个体中的加强抗体反应。60名符合18岁常规加强接种条件的个体，每人接种一剂白喉破伤风疫苗中5Lf的白喉类毒素。采用双抗原ELISA法评估抗体水平。配对ELISA中的离液剂破坏用于检测抗体亲和力。初始抗体水平<1IU/ml的个体，1个月后初始抗体浓度与最高抗体浓度之比高出10倍以上，6个月后仍高出4倍。初始抗体水平≥1IU/ml的个体，6个月后与初始水平相比下降了两倍。因此，对于初始对白喉具有长期保护作用（抗体水平≥1IU/ml）的个体进行疫苗接种是不必要的，应予以避免。