Walory J, Grzesiowski P, Hryniewicz W
Centralnego Laboratorium Surowic i Szczepionek Zakładu Immunologii i Profilaktyki Zakazeń.
Pol Merkur Lekarski. 2000 Oct;9(52):687-92.
The aim of the study was to evaluate immunity against diphtheria and tetanus in healthy adult population in Poland. For determination of antitoxin IgG antibody, toxoid enzyme-linked immunosorbent assay (Toxoid-ELISA) was used. Serum samples were obtained from different regions of Poland and titrated for diphtheria (n = 2442) and tetanus (n = 827) IgG antitoxin. For calibration of anti-toxins determination, the WHO standard of human diphtheria and tetanus antitoxin was used. About 32% (n = 787) of persons were non-protected against diphtheria (IgG-DTAb < 0.1 IU/ml) and 24% (n = 195) against tetanus (IgG-TTAb < 0.1 IU/ml). In 63% (n = 1528) individuals basic protection for diphtheria and 48% (n = 402) for tetanus (0.1-1.0 IU/ml IgG-DTAb and IgG-TTAb) were observed. Only 5% (n = 127) were fully protected for diphtheria and 28% (n = 230) for tetanus (IgG-DTAb and IgG-TTAb > 1.0 IU/ml). In adults between 30-64 years of age, not vaccinated at least during last 10 years, 43% of persons were non-protected. The study showed insufficient immunity against diphtheria in adults. We indicate booster immunisation for selected group of persons.
该研究的目的是评估波兰健康成年人群对白喉和破伤风的免疫力。为了测定抗毒素IgG抗体，使用了类毒素酶联免疫吸附测定法（类毒素-ELISA）。血清样本取自波兰不同地区，并针对白喉（n = 2442）和破伤风（n = 827）IgG抗毒素进行滴定。为了校准抗毒素测定，使用了世界卫生组织的人白喉和破伤风抗毒素标准品。约32%（n = 787）的人对白喉无保护作用（IgG-DTAb < 0.1 IU/ml），24%（n = 195）的人对破伤风无保护作用（IgG-TTAb < 0.1 IU/ml）。在63%（n = 1528）的个体中观察到对白喉的基本保护作用，48%（n = 402）的个体对破伤风有基本保护作用（IgG-DTAb和IgG-TTAb为0.1 - 1.0 IU/ml）。只有5%（n = 127）的人对白喉有完全保护作用，28%（n = 230）的人对破伤风有完全保护作用（IgG-DTAb和IgG-TTAb > 1.0 IU/ml）。在30 - 64岁、至少在过去10年未接种疫苗的成年人中，43%的人无保护作用。该研究表明成年人对白喉的免疫力不足。我们建议对特定人群进行加强免疫。
