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首发精神病的早期干预——一项社区发展活动的影响

Early intervention in first-episode psychosis--the impact of a community development campaign.

作者信息

Krstev Helen, Carbone Steve, Harrigan Susy M, Curry Christina, Elkins Kathryn, McGorry Patrick D

机构信息

Early Psychosis Prevention & Intervention Centre, Locked Bag 10, Parkville (Vic) 3052, Australia.

出版信息

Soc Psychiatry Psychiatr Epidemiol. 2004 Sep;39(9):711-9. doi: 10.1007/s00127-004-0798-5.

Abstract

OBJECTIVE

Substantial delays in providing access to treatment in first-episode psychosis have been well documented. The present study examines the impact of strategies aimed at improving access and reducing delays.

METHOD

A pilot community education campaign was conducted with the aim of reducing the duration of untreated psychosis (DUP) in a geographically defined intervention sector located in the northwestern region of Melbourne, Australia. Utilising a quasi-experimental design, a comparison sector with similar demographics was selected from another part of the north-western region. A mobile early detection team and the same treatment system served both sectors.

RESULTS

While there was no significant difference between the mean DUP for intervention and comparison sectors, the distributional features of DUP between the two regions were significantly different. In the intervention sector, disproportionately more cases with very long DUP were detected. When a small number of outliers were removed, the mean and median DUP in the intervention sector was reduced.

CONCLUSION

These findings highlight the complexity of treatment access and delay and suggest that efforts to reduce DUP may have two effects, not one. Firstly, a different sample of cases is treated through the detection of hidden "long DUP" cases that otherwise may have remained untreated. Secondly, the DUP for the remainder may indeed be reduced. More research with larger samples and more potent campaign strategies is clearly required. It may also be worth considering whether there is a safe and ethical way to undertake a RCT of early versus delayed antipsychotic treatment to perhaps settle the DUP debate once and for all.

摘要

目的

首次发作精神病患者在获得治疗方面存在显著延迟,这已得到充分记录。本研究考察旨在改善治疗可及性并减少延迟的策略的影响。

方法

在澳大利亚墨尔本西北部一个地理界定的干预区域开展了一项试点社区教育活动,目的是缩短未治疗精神病持续时间(DUP)。采用准实验设计,从西北部另一区域选取了一个人口统计学特征相似的对照区域。一个移动早期检测团队和相同的治疗系统服务于两个区域。

结果

虽然干预区域和对照区域的平均DUP没有显著差异,但两个区域之间DUP的分布特征显著不同。在干预区域,检测到的DUP极长的病例比例过高。去除少数离群值后,干预区域的平均和中位数DUP降低。

结论

这些发现凸显了治疗可及性和延迟的复杂性,并表明减少DUP的努力可能有两种效果,而非一种。首先,通过检测隐藏的“长DUP”病例来治疗不同的病例样本,否则这些病例可能仍未得到治疗。其次,其余病例的DUP可能确实会降低。显然需要对更大样本和更有效的活动策略进行更多研究。或许也值得考虑是否有一种安全且符合伦理的方法来进行早期与延迟抗精神病药物治疗的随机对照试验,以便一劳永逸地解决DUP的争议。

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