Norman R M, Malla A K
Department of Psychiatry, University of Western Ontario, London, Canada.
Psychol Med. 2001 Apr;31(3):381-400. doi: 10.1017/s0033291701003488.
The concept of duration of untreated psychosis (DUP) has recently attracted much interest because of its possible relationship to treatment outcome and implications for preventive efforts with reference to psychotic disorders, especially schizophrenia. In this paper we review critically the literature concerning the concept and its importance.
Articles concerned with measuring DUP and those that have been suggested to provide indirect or direct evidence of the effect of DUP on treatment outcome are reviewed.
Evidence thus far suggests that DUP may be related to ease of reducing psychotic symptoms once treatment begins for first episode patients, but there is no evidence of a relationship to likelihood of relapse. There has been little investigation of the relationship of DUP to other long-term outcomes such as negative symptoms and cognitive functioning neither have the possible confounds of DUP been widely investigated or controlled.
It is important that there should be more thorough investigations of DUP, its correlates, and the extent to which it does mediate any advantages of earlier intervention.
未治疗精神病持续时间（DUP）的概念最近引起了广泛关注，因为它可能与治疗结果相关，并且对于精神病性障碍尤其是精神分裂症的预防工作具有重要意义。在本文中，我们对有关该概念及其重要性的文献进行了批判性综述。
对涉及测量DUP的文章以及那些被认为提供了DUP对治疗结果影响的间接或直接证据的文章进行了综述。
迄今为止的证据表明，对于首发患者，一旦开始治疗，DUP可能与减轻精神病症状的难易程度有关，但没有证据表明其与复发可能性有关。关于DUP与其他长期结果（如阴性症状和认知功能）之间的关系研究很少，DUP可能存在的混杂因素也未得到广泛研究或控制。
重要的是，应该对DUP、其相关因素以及它在多大程度上介导早期干预的优势进行更全面的研究。
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