Ackermann Lutz
Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, D-81377 München, Germany.
Org Lett. 2005 Feb 3;7(3):439-42. doi: 10.1021/ol047649j.
[reaction: see text] Highly flexible and efficient syntheses of the indole backbone are presented starting from o-alkynylhaloarenes. These transformations proceed via a palladium- or a copper-catalyzed amination reaction and a subsequent cyclization reaction in good to excellent yields. Furthermore, a multicatalytic one-pot indole synthesis starting from o-chloroiodobenzene is viable using a single catalyst consisting of an N-heterocyclic carbene palladium complex and CuI.
[反应：见正文] 报道了从邻炔基卤代芳烃出发，对吲哚骨架进行高度灵活且高效的合成方法。这些转化过程通过钯催化或铜催化的胺化反应以及随后的环化反应进行，产率良好至优异。此外，使用由N-杂环卡宾钯络合物和CuI组成的单一催化剂，从邻氯碘苯出发进行多催化一锅法吲哚合成是可行的。
