Parsons M W, Gold P E
Department of Psychology, University of Virginia, Charlottesville 22903.
Behav Neural Biol. 1992 Jan;57(1):90-2. doi: 10.1016/0163-1047(92)90801-a.
This experiment determined whether centrally administered glucose can attenuate scopolamine-induced deficits in spontaneous alternation performance. All rats were surgically prepared with indwelling cannulae directed at the lateral ventricle. Thirty min prior to alternation tests, rats received systemic (ip) injections of saline or scopolamine (3 mg/kg). Ten or thirty min prior to training, the rats also received a direct injection into the lateral ventricle of either artificial cerebrospinal fluid (CSF) or glucose (3 micrograms in 1 microliter). Scopolamine significantly impaired spontaneous alternation performance relative to controls. Additional treatment with ICV glucose 30 min, but not 10 min prior to testing, significantly attenuated the scopolamine-induced deficit. These results add support to the view that glucose acts directly on brain systems to attenuate behavioral effects of cholinergic antagonists.
本实验旨在确定中枢给予葡萄糖是否能减轻东莨菪碱诱导的自发交替行为缺陷。所有大鼠均通过手术植入指向侧脑室的留置套管。在交替试验前30分钟，大鼠接受生理盐水或东莨菪碱（3毫克/千克）的腹腔注射。在训练前10或30分钟，大鼠还接受了向侧脑室内直接注射人工脑脊液（CSF）或葡萄糖（1微升中含3微克）。与对照组相比，东莨菪碱显著损害了自发交替行为表现。在测试前30分钟而非10分钟给予脑室内葡萄糖的额外处理，显著减轻了东莨菪碱诱导的缺陷。这些结果支持了葡萄糖直接作用于脑系统以减轻胆碱能拮抗剂行为效应的观点。
