de Craen A J M, Posthuma D, Remarque E J, van den Biggelaar A H J, Westendorp R G J, Boomsma D I
Section Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Center, Leiden, Netherlands.
Genes Immun. 2005 Mar;6(2):167-70. doi: 10.1038/sj.gene.6364162.
Cytokines are key players in numerous inflammatory processes. Demonstration of a heritable component in the variation of cytokine production would indicate that simultaneous occurrence of conditions might be caused by a heritable inflammatory characteristic. We applied an extended twin study approach to assess heritability estimates of interleukin (IL)-1beta, IL-1ra, IL-10, IL-6, and TNF-alpha production capacity after ex vivo stimulation with lipopolysaccharide. Cytokine production capacity was assessed in 42 monozygotic pairs, 52 dizygotic pairs, one trizygotic triplet, 33 single twins, and 83 additional siblings. Heritability estimates were derived from variance decomposition models using maximum likelihood estimation. For all cytokines, over 50% of the variance was genetically determined. IL-1ra and TNF-alpha had the lowest heritability estimate of 53%. Estimates for IL-6 and IL-10 were 57 and 62%, respectively. IL-1beta had the highest estimate of 86%. We conclude that the production of cytokines is under tight genetic control.
细胞因子是众多炎症过程中的关键参与者。细胞因子产生变化中可遗传成分的证明表明，多种病症的同时出现可能由一种可遗传的炎症特征引起。我们应用了一种扩展的双生子研究方法，来评估脂多糖体外刺激后白细胞介素（IL）-1β、IL-1受体拮抗剂（IL-1ra）、IL-10、IL-6和肿瘤坏死因子-α（TNF-α）产生能力的遗传度估计值。在42对同卵双胞胎、52对异卵双胞胎、1个三卵三胞胎、33名单胞胎以及83名其他兄弟姐妹中评估了细胞因子产生能力。遗传度估计值来自使用最大似然估计的方差分解模型。对于所有细胞因子，超过50%的方差是由遗传决定的。IL-1ra和TNF-α的遗传度估计值最低，为53%。IL-6和IL-10的估计值分别为57%和62%。IL-1β的估计值最高，为86%。我们得出结论，细胞因子的产生受到严格的遗传控制。
