Araki Chinami, Hayashi Nobuhide, Moriyama Masako, Morinobu Sahoko, Mukai Masahiko, Koshiba Masahiro, Kawano Seiji, Kumagai Shunichi
Department of Clinical Laboratory, Kobe University Hospital, Kobe 650-0017.
Rinsho Byori. 2004 Dec;52(12):966-72.
Rheumatoid factor (RF) has been commonly used as a marker of rheumatoid arthritis (RA). RF can be detected in 60-80% of RA patients, but the specificity is low against other rheumatic diseases patients. We evaluated the diagnostic accuracy of anti-cyclic citrullinated peptide antibody (anti-CCP), a new diagnostic test for RA. Anti-CCP demonstrated higher sensitivity (81.0%) and specificity (92.4%). By the receiver operating characteristic (ROC) curve analysis, anti-CCP was superior to other markers (ie. RF, CARF, IgG-RF, and MMP-3). In early RA patients (RA patients who had had disease symptoms for < 2 years), sensitivity was 68.8%. Positivities of anti-CCP in RA patients became higher as the advance of stage defined by the Steinbrocker classification. We concluded that anti-CCP is a very valuable tool for the diagnosis of RA. Moreover, anti-CCP is a useful for finding RA of recent onset.
类风湿因子（RF）一直被广泛用作类风湿关节炎（RA）的标志物。60% - 80%的RA患者可检测到RF，但针对其他风湿性疾病患者，其特异性较低。我们评估了抗环瓜氨酸肽抗体（抗CCP）这一RA新诊断试验的诊断准确性。抗CCP显示出更高的敏感性（81.0%）和特异性（92.4%）。通过受试者工作特征（ROC）曲线分析，抗CCP优于其他标志物（即RF、CARF、IgG - RF和MMP - 3）。在早期RA患者（疾病症状出现<2年的RA患者）中，敏感性为68.8%。随着Steinbrocker分类法所定义的病情进展，RA患者中抗CCP的阳性率升高。我们得出结论，抗CCP是诊断RA的非常有价值的工具。此外，抗CCP对于发现近期发病的RA也很有用。
