Rossi C R, Foletto M, Mocellin S, Pilati P, Quintieri L, De Salvo G L, Nitti D, Lise M
Clinica Chirurgica II, University of Padova, Italy.
J Chemother. 2004 Nov;16 Suppl 5:58-61. doi: 10.1080/1120009x.2004.11782387.
We report here the results of 27 patients who underwent hyperthermic isolated limb perfusion with low-dose TNFalpha (1 mg) and doxorubicin (8.5 mg/l of limb volume) for locally advanced soft tissue sarcomas. A tumor response was observed in 85% of cases. After a median follow-up of 30 months, limb salvage and local disease control were achieved in 82 and 85% of patients, respectively. Locoregional toxicity was low or mild in 14 patients, while 2 patients had severe limb toxicity. Systemic side effects were negligible. The perfusate/plasma area under the curve (AUC) ratio for TNFalpha was 56. HILP with low-dose TNFalpha and DXR proved to be an active neoadjuvant drug regimen against limb-threatening STS.
我们在此报告27例接受低剂量肿瘤坏死因子α（1毫克）和阿霉素（8.5毫克/肢体体积）热灌注隔离肢体治疗局部晚期软组织肉瘤患者的结果。85%的病例观察到肿瘤反应。中位随访30个月后，分别有82%和85%的患者实现了肢体挽救和局部疾病控制。14例患者局部区域毒性低或轻微，而2例患者有严重的肢体毒性。全身副作用可忽略不计。肿瘤坏死因子α的灌注液/血浆曲线下面积（AUC）比值为56。低剂量肿瘤坏死因子α和阿霉素的热灌注隔离肢体治疗被证明是一种针对威胁肢体的软组织肉瘤的有效新辅助药物方案。
