Gourley M F, Kisch W J, Mojcik C F, King L B, Krieg A M, Steinberg A D
Cellular Immunology Section, NIAMS, National Institutes of Health, Bethesda, MD 20892.
DNA Cell Biol. 1992 Apr;11(3):253-7. doi: 10.1089/dna.1992.11.253.
Systemic lupus erythematosus is an immune-mediated disease in which the etiology is unknown. Full-length (8.4 kb), type C, modified polytropic (Mpmv) retroviral transcripts from the thymus are characteristic of murine lupus. Reciprocal bone marrow transplantation studies determined that this thymic expression maps to the pre-T bone marrow stem cell. In vitro and in vivo oligonucleotide antisense work suggest that type C retroviruses play a role in immune activation. This paper summarizes our studies of endogenous retroviruses in murine lupus.
系统性红斑狼疮是一种病因不明的免疫介导疾病。来自胸腺的全长（8.4 kb）C型、修饰多嗜性（Mpmv）逆转录病毒转录本是小鼠狼疮的特征。相互骨髓移植研究确定这种胸腺表达定位于前T骨髓干细胞。体外和体内寡核苷酸反义研究表明C型逆转录病毒在免疫激活中起作用。本文总结了我们对小鼠狼疮内源性逆转录病毒的研究。
