Mukherjee Jogeshwar, Christian Bradley T, Narayanan Tanjore K, Shi Bingzhi, Collins Daphne
Brain Imaging Center, Department of Psychiatry and Human Behavior, University of California-Irvine, 162 Irvine Hall, Irvine, CA 92697, USA.
Brain Res. 2005 Jan 25;1032(1-2):77-84. doi: 10.1016/j.brainres.2004.11.005.
The ability to measure amphetamine-induced dopamine release in extrastriatal brain regions in the non-human primates was evaluated by using the dopamine D-2/D-3 receptor radioligand, (18)F-fallypride. These regions included the thalamus, amygdala, pituitary, temporal cortex and frontal cortex as well as putamen, caudate and ventral striatum. The positron emission tomography (PET) studies involved control studies, which extended to 3 h, and the amphetamine-challenge studies, which involved administration of d-amphetamine (approx. 0.5-1 mg/kg, i.v.). PET data analysis employed the distribution volume ratio method (DVR) in which the cerebellum was used as a reference region. Our results show a substantial decrease in the binding potential of (18)F-fallypride in extrastriatal regions: thalamus (-20%), amygdala (-39%) and pituitary (-14%). Putamen, caudate and ventral striatum also exhibited significant decreases (-20%). The decrease in (18)F-fallypride binding in the extrastriatal regions points to the importance of dopaminergic neurotransmission in these brain regions. Furthermore, our findings support the use of (18)F-fallypride to measure extrastriatal dopamine release.
通过使用多巴胺D-2/D-3受体放射性配体（18）F-氟哌利多，评估了在非人类灵长类动物的纹状体以外脑区测量苯丙胺诱导的多巴胺释放的能力。这些区域包括丘脑、杏仁核、垂体、颞叶皮质和额叶皮质以及壳核、尾状核和腹侧纹状体。正电子发射断层扫描（PET）研究包括持续3小时的对照研究以及涉及静脉注射d-苯丙胺（约0.5-1mg/kg）的苯丙胺激发研究。PET数据分析采用分布体积比方法（DVR），其中小脑用作参考区域。我们的结果显示，（18）F-氟哌利多在纹状体以外区域的结合潜力大幅下降：丘脑（-20%）、杏仁核（-39%）和垂体（-14%）。壳核、尾状核和腹侧纹状体也表现出显著下降（-20%）。纹状体以外区域（18）F-氟哌利多结合的下降表明多巴胺能神经传递在这些脑区的重要性。此外，我们的研究结果支持使用（18）F-氟哌利多来测量纹状体以外的多巴胺释放。
