Yang Wei
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
FEBS Lett. 2005 Feb 7;579(4):868-72. doi: 10.1016/j.febslet.2004.11.047.
Members of the Y-family of DNA polymerases catalyze template-dependent DNA synthesis but share no sequence homology with other known DNA polymerases. Y-family polymerases exhibit high error rates and low processivity when copying normal DNA but are able to synthesize DNA opposite damaged templates. In the past three years, much has been learned about this family of polymerases including determination of more than a dozen crystal structures with various substrates. In this short review, I will summarize the biochemical properties and structural features of Y-family DNA polymerases.
Y 家族 DNA 聚合酶成员催化依赖模板的 DNA 合成，但与其他已知的 DNA 聚合酶没有序列同源性。Y 家族聚合酶在复制正常 DNA 时表现出高错误率和低持续合成能力，但能够在受损模板的对面合成 DNA。在过去三年里，人们对这个聚合酶家族有了很多了解，包括确定了十几种与各种底物的晶体结构。在这篇简短的综述中，我将总结 Y 家族 DNA 聚合酶的生化特性和结构特征。
