实验性孢子丝菌病中针对可溶性和分级分离抗原的体液免疫反应。
Humoral immune response against soluble and fractionate antigens in experimental sporotrichosis.
作者信息
Nascimento Rosana C, Almeida Sandro Rogério
机构信息
Departamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, Av. Prof. Lineu Prestes 580, Bloco 17, 05508-900, São Paulo, Brazil.
出版信息
FEMS Immunol Med Microbiol. 2005 Feb 1;43(2):241-7. doi: 10.1016/j.femsim.2004.08.004.
Sporotrichosis is a chronic granulomatous mycosis caused by the dimorphic fungus Sporothrix schenckii, which is widely distributed in nature, and presents a saprophytic mycelial form on plant debris and soil. The immunological mechanisms involved in the prevention and control of sporotrichosis are not yet fully understood. In this study, mice were studied after infection with Sporothrix schenckii. In the first week after infection, fungal loading increased and thence decreased drastically 14 days after infection. Analysis by immunoblotting showed that the sera of all mice tested had antibodies reacting only with a 70 kDa antigen, with predominance of IgG1 and IgG3. Taken together, our results show that antigens from S. schenckii induced a specific humoral response in infected mice.
孢子丝菌病是一种由双相真菌申克孢子丝菌引起的慢性肉芽肿性真菌病。申克孢子丝菌广泛分布于自然界，在植物残体和土壤中呈腐生菌丝形态。目前，人们对参与孢子丝菌病防治的免疫机制尚未完全了解。在本研究中，对感染申克孢子丝菌的小鼠进行了研究。感染后的第一周，真菌载量增加，之后在感染14天后急剧下降。免疫印迹分析表明，所有受试小鼠的血清中均有仅与一种70 kDa抗原发生反应的抗体，其中以IgG1和IgG3为主。综上所述，我们的结果表明，申克孢子丝菌抗原在感染小鼠中诱导了特异性体液反应。
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