Nava-Pérez Nallely, Neri-García Lisset G, Romero-González Oscar E, Terrones-Cruz Joshua A, García-Carnero Laura C, Mora-Montes Héctor M
Departamento de Biología, División de Ciencias Naturales y Exactas, Campus Guanajuato, Universidad de Guanajuato, Guanajuato, 36050, Gto., México.
Infect Drug Resist. 2022 Apr 22;15:2067-2090. doi: 10.2147/IDR.S362099. eCollection 2022.
Sporotrichosis is an important subcutaneous mycosis with high prevalence and threat to human and animal health worldwide. , and are the main etiological agents of this disease; and even though many efforts have been made recently to understand the -host interaction, little is known about , an underestimated species. This organism shows the lowest virulence among the members of the pathogenic clade and represents an important pathogenic agent due to its global distribution. Here, we offer a review with all the known information about , including its genome and proteomic information, and compare it with and , to explain the differences observed among these species, in terms of virulence, the host immune response, and the antifungal sensitivity. Also, we provide the gene prediction of some putative virulence factors.
孢子丝菌病是一种重要的皮下真菌病，在全球范围内对人类和动物健康具有高患病率和威胁。申克孢子丝菌、巴西孢子丝菌和球形孢子丝菌是该疾病的主要病原体；尽管最近为了解病原体与宿主的相互作用做出了许多努力，但对于被低估的物种申克孢子丝菌所知甚少。该病原体在申克孢子丝菌致病进化枝成员中显示出最低的毒力，并且由于其全球分布而代表一种重要的病原体。在这里，我们对申克孢子丝菌的所有已知信息进行综述，包括其基因组和蛋白质组信息，并将其与巴西孢子丝菌和球形孢子丝菌进行比较，以解释在这些物种之间观察到的毒力、宿主免疫反应和抗真菌敏感性方面的差异。此外，我们提供了一些申克孢子丝菌假定毒力因子的基因预测。
