Biological and Clinical Attributes of , a Causative Agent of Sporotrichosis.

Sporotrichosis is an important subcutaneous mycosis with high prevalence and threat to human and animal health worldwide. , and are the main etiological agents of this disease; and even though many efforts have been made recently to understand the -host interaction, little is known about , an underestimated species. This organism shows the lowest virulence among the members of the pathogenic clade and represents an important pathogenic agent due to its global distribution. Here, we offer a review with all the known information about , including its genome and proteomic information, and compare it with and , to explain the differences observed among these species, in terms of virulence, the host immune response, and the antifungal sensitivity. Also, we provide the gene prediction of some putative virulence factors.