家族性地中海热中的干扰素-γ水平

Interferon-gamma levels in familial Mediterranean fever.

作者信息

Köklü Seyfettin, Oztürk Mehmet Akif, Balci Mustafa, Yüksel Osman, Ertenli Ihsan, Kiraz Sedat

机构信息

Department of Gastroenterology, Türkiye Yüksek Ihtisas Hospital, Ankara, Turkey.

出版信息

Joint Bone Spine. 2005 Jan;72(1):38-40. doi: 10.1016/j.jbspin.2004.03.011.

DOI:10.1016/j.jbspin.2004.03.011

PMID:15681246

Abstract

AIMS

To evaluate the levels of endogenous interferon-gamma (IFN-gamma) in patients with familial Mediterranean fever (FMF).

METHODS

Plasma levels of IFN-gamma were assayed in 29 FMF patients in attack-free period (mean age: 32, min-max: 17-48; male/female: 10/19), 18 FMF patients with acute FMF attack (mean age: 32, min-max: 19-50; male/female: 8/10), and 19 healthy controls (mean age: 31.94 +/- 1.50, min-max: 23-42; male/female: 11/8). IFN-gamma levels were also compared among colchicine treated and untreated groups.

RESULTS

Median plasma IFN-gamma levels were significantly higher in patients both with and without FMF attack than the control group (P < 0.05). Moreover, plasma IFN-gamma levels were higher in patients with acute FMF attack compared to patients in attack-free periods (P < 0.05). Plasma levels of IFN-gamma were comparable in colchicine treated and untreated groups.

CONCLUSION

Our results suggest that IFN-gamma may contribute to the inflammatory cascade of FMF.

摘要

目的

评估家族性地中海热（FMF）患者体内内源性干扰素-γ（IFN-γ）的水平。

方法

检测29例处于无发作期的FMF患者（平均年龄：32岁，最小-最大年龄：17 - 48岁；男/女：10/19）、18例急性发作期的FMF患者（平均年龄：32岁，最小-最大年龄：19 - 50岁；男/女：8/10）以及19名健康对照者（平均年龄：31.94 ± 1.50岁，最小-最大年龄：23 - 42岁；男/女：11/8）的血浆IFN-γ水平。还比较了秋水仙碱治疗组和未治疗组的IFN-γ水平。