Kiraz S, Ertenli I, Arici M, Calgüneri M, Haznedaroglu I, Celik I, Pay S, Kirazli S
Hacettepe University, School of Medicine, Department of Internal Medicine, Ankara, Turkey.
Clin Exp Rheumatol. 1998 Nov-Dec;16(6):721-4.
To evaluate whether basal levels of circulating cytokines and selectins exhibit a distinct profile in attack-free, non-colchicine taking familial Mediterranean fever (FMF) patients compared to normal healthy controls, and to determine the effect of colchicine treatment on these parameters.
Serum levels of interleukin (IL)-6, IL-8, tumor necrosis factor (TNF)-alpha, and soluble P-, E-, and L-selectin in attack-free, asymptomatic, non-colchicine using FMF patients (n = 11) and in normal controls (n = 10) were studied. Following 2 months of colchicine treatment the same parameters were evaluated again in the FMF patients.
Before colchicine treatment the serum levels of all parameters except soluble P-selectin were significantly higher in FMF patients than in controls. After two months of treatment statistically significant decreases were observed in these parameters (p < 0.05).
A distinct profile of IL-6, IL-8, TNF-alpha, and soluble E- and L-selectin levels was observed in FMF patients, which could reflect the presence of sustained inflammation in attack-free FMF patients. The effect of colchicine on these parameters suggests its therapeutic potential.
评估无发作、未服用秋水仙碱的家族性地中海热（FMF）患者与正常健康对照相比，循环细胞因子和选择素的基础水平是否呈现不同特征，并确定秋水仙碱治疗对这些参数的影响。
研究了无发作、无症状、未使用秋水仙碱的FMF患者（n = 11）和正常对照（n = 10）血清中白细胞介素（IL）-6、IL-8、肿瘤坏死因子（TNF）-α以及可溶性P-、E-和L-选择素的水平。在FMF患者接受2个月秋水仙碱治疗后，再次评估相同参数。
在秋水仙碱治疗前，除可溶性P-选择素外，FMF患者所有参数的血清水平均显著高于对照组。治疗2个月后，这些参数出现统计学上的显著下降（p < 0.05）。
在FMF患者中观察到IL-6、IL-8、TNF-α以及可溶性E-和L-选择素水平的独特特征，这可能反映了无发作的FMF患者存在持续性炎症。秋水仙碱对这些参数的影响表明了其治疗潜力。
