Yildirim Cetin Gozde, Gul Ozlem, Kesici-Metin Fatma, Gokalp İrem, Sayarlıoglu Mehmet
Division of Rheumatology, Department of Internal Medicine, School of Medicine, Faculty of Medicine, Sutcu Imam University, 46050 Kahramanmaras, Turkey.
Division of Hematology, Department of Pediatrics, School of Medicine, Sutcu Imam University, 46050 Kahramanmaras, Turkey.
Int J Chronic Dis. 2014;2014:127426. doi: 10.1155/2014/127426. Epub 2014 Mar 12.
In this paper we want to demonstrate whether higher than normal levels of RDW, and lower than normal levels of MPV can be used as indicators of subclinical inflammation and tools for treatment decision in FMF or not. The participants in this study included 89 patients with FMF during attack-free periods and 30 healthy controls. The RDW and platelet counts were significantly higher, while the MPV was significantly lower in the patients with FMF group than healthy control group (P < 0.001; P = 0.005; P < 0.001, resp.). In the attack-free FMF group, a negative correlation was found between the MPV and RDW values (P < 0.001, r = -0.40). The positive correlation was found between the RDW and ESR (r = 0.23, P = 0.028). And the negative correlation was found between the MPV and CRP (r = -0.216, P = 0.042). Consequently, our results suggest that low MPV and high RDW levels may provide additional information about subclinical inflammation in FMF patients. But other strong predisposing factors affecting subclinical inflammation in FMF should be considered. Further studies with large numbers of patients are needed. Treatment of FMF should include not only prevention of acute attacks but also decreasing of the subclinical inflammation.
在本文中，我们想要证明高于正常水平的红细胞分布宽度（RDW）和低于正常水平的平均血小板体积（MPV）是否可以用作家族性地中海热（FMF）亚临床炎症的指标以及治疗决策的工具。本研究的参与者包括89例处于无发作期的FMF患者和30名健康对照者。FMF组患者的RDW和血小板计数显著更高，而MPV显著低于健康对照组（分别为P < 0.001；P = 0.005；P < 0.001）。在无发作的FMF组中，发现MPV与RDW值之间呈负相关（P < 0.001，r = -0.40）。发现RDW与红细胞沉降率（ESR）之间呈正相关（r = 0.23，P = 0.028）。并且发现MPV与C反应蛋白（CRP）之间呈负相关（r = -0.216，P = 0.042）。因此，我们的结果表明低MPV和高RDW水平可能为FMF患者的亚临床炎症提供额外信息。但应考虑其他影响FMF亚临床炎症的强大诱发因素。需要对大量患者进行进一步研究。FMF的治疗不仅应包括预防急性发作，还应包括减轻亚临床炎症。
